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    Zfp335 zinc finger protein 335 [ Mus musculus (house mouse) ]

    Gene ID: 329559, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfp335provided by MGI
    Official Full Name
    zinc finger protein 335provided by MGI
    Primary source
    MGI:MGI:2682313
    See related
    Ensembl:ENSMUSG00000039834 AllianceGenome:MGI:2682313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nif1; NIF-1; Znf335; 1810045J01Rik
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone methyltransferase binding activity. Involved in brain development; neuron projection morphogenesis; and positive regulation of neuroblast proliferation. Acts upstream of or within several processes, including brain development; in utero embryonic development; and regulation of neurogenesis. Located in nucleus. Part of histone methyltransferase complex. Is expressed in brain and future brain. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZNF335 (zinc finger protein 335). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 31.4), spleen adult (RPKM 20.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Zfp335 in Genome Data Viewer
    Location:
    2 H3; 2 85.27 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164733802..164756034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164891882..164912585, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930445K14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6019 Neighboring gene STARR-positive B cell enhancer ABC_E2059 Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene predicted gene, 46775 Neighboring gene STARR-seq mESC enhancer starr_06342 Neighboring gene zinc finger protein 335, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164764412-164764521 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164768440-164768694 Neighboring gene matrix metallopeptidase 9 Neighboring gene solute carrier family 12, member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (3)  1 citation
    • Transgenic (1) 

    General gene information

    Clone Names

    • MGC86001

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within brain morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epigenetic regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lymphocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 335
    Names
    NRC-interacting factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199027.2NP_950192.2  zinc finger protein 335

      See identical proteins and their annotated locations for NP_950192.2

      Status: VALIDATED

      Source sequence(s)
      BC062921, CN721033
      Consensus CDS
      CCDS38331.1
      UniProtKB/Swiss-Prot
      A2A5K6, B2RXR9, Q3TZT1
      Related
      ENSMUSP00000038298.8, ENSMUST00000041361.14
      Conserved Domains (4) summary
      COG5189
      Location:10261126
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:10491069
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:10891114
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:10751099
      zf-H2C2_5; C2H2-type zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164733802..164756034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251805.2XP_030107665.1  zinc finger protein 335 isoform X1

      Conserved Domains (4) summary
      COG5189
      Location:10271127
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:10501070
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:10901115
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:10761100
      zf-H2C2_5; C2H2-type zinc-finger domain
    2. XM_030251807.2XP_030107667.1  zinc finger protein 335 isoform X2

      UniProtKB/Swiss-Prot
      A2A5K6, B2RXR9, Q3TZT1
      Conserved Domains (4) summary
      COG5189
      Location:10261126
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:10491069
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:10891114
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:10751099
      zf-H2C2_5; C2H2-type zinc-finger domain
    3. XM_030251806.2XP_030107666.1  zinc finger protein 335 isoform X1

      Conserved Domains (4) summary
      COG5189
      Location:10271127
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:10501070
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:10901115
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:10761100
      zf-H2C2_5; C2H2-type zinc-finger domain
    4. XM_036162334.1XP_036018227.1  zinc finger protein 335 isoform X2

      UniProtKB/Swiss-Prot
      A2A5K6, B2RXR9, Q3TZT1
      Conserved Domains (4) summary
      COG5189
      Location:10261126
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:10491069
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:10891114
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:10751099
      zf-H2C2_5; C2H2-type zinc-finger domain