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    MTCL3 MTCL family member 3 [ Homo sapiens (human) ]

    Gene ID: 387104, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MTCL3provided by HGNC
    Official Full Name
    MTCL family member 3provided by HGNC
    Primary source
    HGNC:HGNC:21494
    See related
    Ensembl:ENSG00000214338 AllianceGenome:HGNC:21494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SOGA3; C6orf174; dJ403A15.3
    Summary
    Predicted to be involved in regulation of autophagy. Predicted to be located in extracellular space and membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 11.8), fat (RPKM 5.6) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MTCL3 in Genome Data Viewer
    Location:
    6q22.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (127472974..127519335, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (128661901..128708261, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (127794119..127840480, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SOGA3-KIAA0408 readthrough Neighboring gene KIAA0408 Neighboring gene uncharacterized LOC124901399 Neighboring gene Sharpr-MPRA regulatory region 7566 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:127802337-127803536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25041 Neighboring gene uncharacterized LOC107986642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:127835952-127836476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17530 Neighboring gene chromosome 6 open reading frame 58 Neighboring gene uncharacterized LOC105377995

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. Ku WC, et al. Mol Cell Proteomics, 2009 Sep. PMID 19505873, Free PMC Article
    2. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
    3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. Emdal KB, et al. Sci Signal, 2015 Apr 28. PMID 25921289
    4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
    5. TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing. Demirdizen E, et al. Neuro Oncol, 2023 Jun 2. PMID 36215168, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough SOGA3-KIAA0408

    Readthrough gene: SOGA3-KIAA0408, Included gene: KIAA0408

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule cross-linking factor 3
    Names
    SOGA family member 3
    protein SOGA3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400265.1 → NP_001387194.1  microtubule cross-linking factor 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL096711, AL583806
      Consensus CDS
      CCDS43505.1
      UniProtKB/Swiss-Prot
      Q5TF21
      UniProtKB/TrEMBL
      E9PJP2
      Related
      ENSP00000434570.1, ENST00000525778.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      127472974..127519335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      128661901..128708261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001012279.3: Suppressed sequence

      Description
      NM_001012279.3: This RefSeq was removed because currently there is insufficient support for the transcript.

    2. NM_001395923.1: Suppressed sequence

      Description
      NM_001395923.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    3. NM_001395924.1: Suppressed sequence

      Description
      NM_001395924.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    4. NM_001395925.1: Suppressed sequence

      Description
      NM_001395925.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    5. NM_001395926.1: Suppressed sequence

      Description
      NM_001395926.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    6. NM_001395928.1: Suppressed sequence

      Description
      NM_001395928.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    7. NM_001395929.1: Suppressed sequence

      Description
      NM_001395929.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TF21.1 GenPept UniProtKB/Swiss-Prot:Q5TF21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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