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    SIRT2 sirtuin 2 [ Homo sapiens (human) ]

    Gene ID: 22933, updated on 4-Jan-2025

    Summary

    Official Symbol
    SIRT2provided by HGNC
    Official Full Name
    sirtuin 2provided by HGNC
    Primary source
    HGNC:HGNC:10886
    See related
    Ensembl:ENSG00000068903 MIM:604480; AllianceGenome:HGNC:10886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIR2; SIR2L; SIR2L2
    Summary
    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in brain (RPKM 37.1), ovary (RPKM 15.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SIRT2 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38878555..38899618, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41682611..41703673, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39369195..39390258, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39333551-39334051 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39338887-39339825 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39339826-39340763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39343185-39343829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10587 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:39350790-39350958 Neighboring gene Sharpr-MPRA regulatory region 3140 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39356343-39356918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39360061-39360631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39360661-39361267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39361268-39361873 Neighboring gene Ras and Rab interactor like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39384205-39384706 Neighboring gene NFKB inhibitor beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39402426-39403052 Neighboring gene coiled-coil glutamate rich protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ35621, FLJ37491

    Gene Ontology Provided by GOA

    Items 1 - 25 of 31
    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding PubMed 
    enables NAD+ binding  
    enables NAD+ binding PubMed 
    NOT enables NAD+-protein ADP-ribosyltransferase activity PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity PubMed 
    NOT enables NAD+-protein poly-ADP-ribosyltransferase activity PubMed 
    enables NAD-dependent protein demyristoylase activity PubMed 
    enables NAD-dependent protein depalmitoylase activity PubMed 
    enables NAD-dependent protein lysine deacetylase activity PubMed 
    enables NAD-dependent protein lysine deacetylase activity PubMed 
    enables NAD-dependent protein lysine deacetylase activity  
    enables chromatin binding PubMed 
    enables histone H3K14 deacetylase activity, NAD-dependent  
    enables histone H3K18 deacetylase activity, NAD-dependent  
    enables histone H3K4 deacetylase activity, NAD-dependent  
    enables histone H3K56 deacetylase activity, NAD-dependent  
    enables histone H3K9 deacetylase activity, NAD-dependent  
    enables histone H4K16 deacetylase activity, NAD-dependent PubMed 
    enables histone acetyltransferase binding PubMed 
    enables histone deacetylase activity PubMed 
    enables histone deacetylase activity, NAD-dependent  
    NOT enables histone deacetylase activity, NAD-dependent PubMed 
    enables histone deacetylase activity, NAD-dependent PubMed 
    enables histone deacetylase binding PubMed 
    enables protein binding PubMed 
    enables protein lysine deacetylase activity PubMed 
    enables protein lysine deacetylase activity PubMed 
    NOT enables tubulin deacetylase activity PubMed 
    enables tubulin deacetylase activity PubMed 
    enables ubiquitin binding PubMed 
    enables zinc ion binding PubMed 
    Items 1 - 25 of 31
    Items 1 - 25 of 53
    Process Evidence Code Pubs
    involved_in NLRP3 inflammasome complex assembly  
    involved_in autophagy  
    involved_in cell division  
    involved_in cellular response to caloric restriction  
    involved_in cellular response to epinephrine stimulus  
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to oxidative stress  
    involved_in epigenetic regulation of gene expression PubMed 
    involved_in heterochromatin formation PubMed 
    involved_in innate immune response  
    involved_in lipid catabolic process  
    involved_in meiotic cell cycle  
    involved_in mitotic nuclear membrane reassembly  
    involved_in myelination in peripheral nervous system  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of NLRP3 inflammasome complex assembly  
    involved_in negative regulation of autophagy PubMed 
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of oligodendrocyte progenitor proliferation  
    involved_in negative regulation of peptidyl-threonine phosphorylation  
    involved_in negative regulation of protein catabolic process PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process  
    involved_in negative regulation of satellite cell differentiation  
    involved_in negative regulation of striated muscle tissue development PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in peptidyl-lysine deacetylation PubMed 
    involved_in positive regulation of DNA binding  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore  
    involved_in positive regulation of cell division  
    involved_in positive regulation of execution phase of apoptosis  
    involved_in positive regulation of fatty acid biosynthetic process PubMed 
    involved_in positive regulation of meiotic nuclear division  
    involved_in positive regulation of oocyte maturation  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in post-translational protein modification  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
    NOT involved_in protein deacetylation PubMed 
    involved_in protein deacetylation PubMed 
    involved_in rDNA heterochromatin formation  
    involved_in rDNA heterochromatin formation PubMed 
    involved_in regulation of cell cycle PubMed 
    involved_in regulation of exit from mitosis PubMed 
    involved_in regulation of myelination  
    involved_in regulation of phosphorylation PubMed 
    involved_in response to redox state PubMed 
    involved_in substantia nigra development PubMed 
    involved_in subtelomeric heterochromatin formation PubMed 
    NOT involved_in tubulin deacetylation PubMed 
    involved_in tubulin deacetylation PubMed 
    involved_in tubulin deacetylation  
    Items 1 - 25 of 53
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    located_in Schmidt-Lanterman incisure  
    located_in centriole PubMed 
    located_in centrosome PubMed 
    part_of chromatin silencing complex PubMed 
    located_in chromosome PubMed 
    located_in chromosome, telomeric region  
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in glial cell projection  
    located_in growth cone  
    located_in heterochromatin  
    located_in juxtaparanode region of axon  
    located_in lateral loop  
    located_in meiotic spindle  
    located_in microtubule PubMed 
    located_in midbody PubMed 
    located_in mitochondrion PubMed 
    located_in mitotic spindle PubMed 
    located_in myelin sheath  
    located_in nucleolus  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in paranodal junction  
    located_in paranode region of axon  
    located_in perikaryon  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in spindle PubMed 
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    NAD-dependent protein deacetylase sirtuin-2
    Names
    NAD-dependent deacetylase sirtuin-2
    NAD-dependent protein defatty-acylase sirtuin-2
    SIR2-like protein 2
    regulatory protein SIR2 homolog 2
    silent information regulator 2
    sir2-related protein type 2
    sirtuin type 2
    NP_001180215.1
    NP_036369.2
    NP_085096.1
    XP_011524957.1
    XP_047294424.1
    XP_047294425.1
    XP_054176249.1
    XP_054176250.1
    XP_054176251.1
    XP_054187933.1
    XP_054187934.1
    XP_054187935.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193286.2NP_001180215.1  NAD-dependent protein deacetylase sirtuin-2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, and also lacks a big segment in the 3' region, resulting in a frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, and a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AF131800, BF529906, DA541045
      Consensus CDS
      CCDS74361.1
      UniProtKB/TrEMBL
      A0A0A0MRF5, E7EWX6
      Related
      ENSP00000351809.6, ENST00000358931.9
      Conserved Domains (1) summary
      cd01408
      Location:40228
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    2. NM_012237.4NP_036369.2  NAD-dependent protein deacetylase sirtuin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF083107, BF529906
      Consensus CDS
      CCDS12523.1
      UniProtKB/Swiss-Prot
      A8K3V1, B2RB45, O95889, Q8IXJ6, Q924Y7, Q9P0G8, Q9UNT0, Q9Y6E9, U5TP13
      UniProtKB/TrEMBL
      A0AAG2T947
      Related
      ENSP00000249396.7, ENST00000249396.12
      Conserved Domains (1) summary
      cd01408
      Location:77331
      SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
    3. NM_030593.3NP_085096.1  NAD-dependent protein deacetylase sirtuin-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      BC003012
      Consensus CDS
      CCDS46069.1
      UniProtKB/TrEMBL
      A0AAG2T947
      Related
      ENSP00000375931.2, ENST00000392081.6
      Conserved Domains (2) summary
      cd01408
      Location:40294
      SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
      pfam16602
      Location:313351
      USP19_linker; Linker region of USP19 deubiquitinase

    RNA

    1. NR_034146.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks the 5' two exons but has an alternate 5' segment, resulting in an upstream open reading frame (uORF) with strong Kozak signal, as compared to variant 1. The uORF overlaps the downstream ORF (dORF), and inhibits the protein translation from the dORF. Therefore, this transcript is a nonsense-mediated mRNA decay candidate and can not make a functional protein.
      Source sequence(s)
      AK290716, BF346568, BF529906

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      38878555..38899618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526655.2XP_011524957.1  NAD-dependent protein deacetylase sirtuin-2 isoform X2

      UniProtKB/Swiss-Prot
      Q8IXJ6
      Conserved Domains (2) summary
      cd01408
      Location:7261
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
      pfam16602
      Location:280318
      USP19_linker; Linker region of USP19 deubiquitinase
    2. XM_047438468.1XP_047294424.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

      UniProtKB/TrEMBL
      A0AAG2T947
    3. XM_047438469.1XP_047294425.1  NAD-dependent protein deacetylase sirtuin-2 isoform X3

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_014040929.1 Reference GRCh38.p14 PATCHES

      Range
      288227..309290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331959.1XP_054187934.1  NAD-dependent protein deacetylase sirtuin-2 isoform X2

    2. XM_054331958.1XP_054187933.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

      UniProtKB/TrEMBL
      A0AAG2T947
    3. XM_054331960.1XP_054187935.1  NAD-dependent protein deacetylase sirtuin-2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      41682611..41703673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320275.1XP_054176250.1  NAD-dependent protein deacetylase sirtuin-2 isoform X2

    2. XM_054320274.1XP_054176249.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

      UniProtKB/TrEMBL
      A0AAG2T947
    3. XM_054320276.1XP_054176251.1  NAD-dependent protein deacetylase sirtuin-2 isoform X3

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