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    Ddx24 DEAD box helicase 24 [ Mus musculus (house mouse) ]

    Gene ID: 27225, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ddx24provided by MGI
    Official Full Name
    DEAD box helicase 24provided by MGI
    Primary source
    MGI:MGI:1351337
    See related
    Ensembl:ENSMUSG00000041645 AllianceGenome:MGI:1351337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700055J08Rik; 2510027P10Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be active in nucleolus. Orthologous to human DDX24 (DEAD-box helicase 24). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 38.5), cortex adult (RPKM 31.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ddx24 in Genome Data Viewer
    Location:
    12 E; 12 52.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103374235..103392106, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103407976..103425847, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4038 Neighboring gene STARR-positive B cell enhancer ABC_E1863 Neighboring gene predicted gene 15523 Neighboring gene STARR-positive B cell enhancer ABC_E7174 Neighboring gene OTU domain, ubiquitin aldehyde binding 2 Neighboring gene STARR-positive B cell enhancer ABC_E4039 Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene predicted gene, 53758 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene interferon, alpha-inducible protein 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX24
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
    DEAD box protein 24
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 13 (RNA helicase A)
    NP_001152974.1
    NP_001351091.1
    NP_001351092.1
    NP_065240.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159502.2NP_001152974.1  ATP-dependent RNA helicase DDX24 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154347, BB006411, BC055317
      Consensus CDS
      CCDS49152.1
      UniProtKB/TrEMBL
      F8WJA0, Q3U7R4
      Related
      ENSMUSP00000105628.3, ENSMUST00000110001.4
      Conserved Domains (3) summary
      COG0513
      Location:238787
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:619727
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:241557
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001364162.1NP_001351091.1  ATP-dependent RNA helicase DDX24 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154347
      Consensus CDS
      CCDS26129.1
      UniProtKB/Swiss-Prot
      Q61119, Q7TM97, Q9ESV0
      UniProtKB/TrEMBL
      Q3U7R4
      Conserved Domains (1) summary
      COG0513
      Location:192741
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    3. NM_001364163.1NP_001351092.1  ATP-dependent RNA helicase DDX24 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154347
      Consensus CDS
      CCDS26129.1
      UniProtKB/Swiss-Prot
      Q61119, Q7TM97, Q9ESV0
      UniProtKB/TrEMBL
      Q3U7R4
      Conserved Domains (1) summary
      COG0513
      Location:192741
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    4. NM_020494.4NP_065240.2  ATP-dependent RNA helicase DDX24 isoform 2

      See identical proteins and their annotated locations for NP_065240.2

      Status: VALIDATED

      Source sequence(s)
      BB006411, BC043721, CJ141277
      Consensus CDS
      CCDS26129.1
      UniProtKB/Swiss-Prot
      Q61119, Q7TM97, Q9ESV0
      UniProtKB/TrEMBL
      Q3U7R4
      Related
      ENSMUSP00000040890.8, ENSMUST00000044923.15
      Conserved Domains (1) summary
      COG0513
      Location:192741
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103374235..103392106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)