Pdcd4 programmed cell death 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdcd4provided by RGD
Official Full Name: programmed cell death 4provided by RGD
Primary source: RGD:620816
See related: EnsemblRapid:ENSRNOG00000014779 AllianceGenome:RGD:620816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dug
Summary: Predicted to enable RNA binding activity. Involved in several processes, including epithelial to mesenchymal transition involved in cardiac fibroblast development; regulation of apoptotic process; and response to alkaloid. Located in nucleus. Orthologous to human PDCD4 (programmed cell death 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 357.6), Thymus (RPKM 315.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (262912659..262949581)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (252921342..252944278)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (274616625..274648204)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates MIF-induced PASMCs proliferation/migration and vascular remodeling.
Title: Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates MIF-induced PASMCs proliferation/migration and vascular remodeling.
Pdcd4 promotes lipid deposition by attenuating PPARalpha-mediated fatty acid oxidation in hepatocytes.
Title: Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes.
Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5.
Title: Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5.
Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury.
Title: Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury.
PDCD4 deficiency ameliorates left ventricular remodeling and insulin resistance in a rat model of type 2 diabetic cardiomyopathy.
Title: PDCD4 deficiency ameliorates left ventricular remodeling and insulin resistance in a rat model of type 2 diabetic cardiomyopathy.
LncRNA-GAS5 regulates PDCD4 expression and mediates myocardial infarction-induced cardiomyocytes apoptosis via targeting MiR-21.
Title: LncRNA-GAS5 regulates PDCD4 expression and mediates myocardial infarction-induced cardiomyocytes apoptosis via targeting MiR-21.
Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP/miR-206/PDCD4 signaling pathway.
Title: Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP/miR-206/PDCD4 signaling pathway.
MiR-340-5p alleviates oxygen-glucose deprivation/reoxygenation-induced neuronal injury via PI3K/Akt activation by targeting PDCD4.
Title: MiR-340-5p alleviates oxygen-glucose deprivation/reoxygenation-induced neuronal injury via PI3K/Akt activation by targeting PDCD4.
PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.
Title: PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.
MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure.
Title: MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure.

Submit: New GeneRIF Correction See all GeneRIFs (33)

General gene information

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Markers

RH93337 (e-PCR)
- UniSTS:83971

RH133731 (e-PCR)
- UniSTS:217014

BE112877 (e-PCR)
- UniSTS:246211

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myofibroblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: programmed cell death protein 4

Names: death up-regulated gene protein; death-upregulated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022265.3 → NP_071601.2 programmed cell death protein 4

See identical proteins and their annotated locations for NP_071601.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9JID1

UniProtKB/TrEMBL

A0A8L2QAG2, B3DM93

Related

ENSRNOP00000020155.4, ENSRNOT00000020155.5

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

262912659..262949581

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272663.1 → XP_063128733.1 programmed cell death protein 4 isoform X1

UniProtKB/Swiss-Prot

Q9JID1

UniProtKB/TrEMBL

B3DM93
XM_063272662.1 → XP_063128732.1 programmed cell death protein 4 isoform X1

UniProtKB/Swiss-Prot

Q9JID1

UniProtKB/TrEMBL

B3DM93

Related

ENSRNOP00000076366.2, ENSRNOT00000119971.2
XM_006231615.5 → XP_006231677.1 programmed cell death protein 4 isoform X1

See identical proteins and their annotated locations for XP_006231677.1

UniProtKB/Swiss-Prot

Q9JID1

UniProtKB/TrEMBL

A0A8L2QAG2, B3DM93

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
XM_006231616.5 → XP_006231678.1 programmed cell death protein 4 isoform X1

See identical proteins and their annotated locations for XP_006231678.1

UniProtKB/Swiss-Prot

Q9JID1

UniProtKB/TrEMBL

A0A8L2QAG2, B3DM93

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
XM_063272661.1 → XP_063128731.1 programmed cell death protein 4 isoform X1

UniProtKB/Swiss-Prot

Q9JID1

UniProtKB/TrEMBL

B3DM93