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    cfp-1 CXXC-type zinc finger protein 1 [ Caenorhabditis elegans ]

    Gene ID: 178363, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cfp-1
    Official Full Name
    CXXC-type zinc finger protein 1
    Primary source
    WormBase:WBGene00009924
    Locus tag
    CELE_F52B11.1
    See related
    AllianceGenome:WB:WBGene00009924
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable methylated histone binding activity. Involved in transdifferentiation. Predicted to be located in nucleus. Predicted to be part of Set1C/COMPASS complex. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cfp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (14077441..14083559)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PX domain-containing protein;Sorting nexin lst-4 Neighboring gene DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein;SAP domain-containing protein Neighboring gene putative phosphomannomutase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extreme HOT regions are CpG-dense promoters in C. elegans and humans. Chen RA, et al. Genome Res, 2014 Jul. PMID 24653213, Free PMC Article
    2. Conserved dual-mode gene regulation programs in higher eukaryotes. Lee JY, et al. Nucleic Acids Res, 2021 Mar 18. PMID 33621342, Free PMC Article
    3. A Role for Caenorhabditis elegans COMPASS in Germline Chromatin Organization. Herbette M, et al. Cells, 2020 Sep 8. PMID 32911802, Free PMC Article
    4. Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans. Caron M, et al. Life Sci Alliance, 2022 Mar. PMID 34893559, Free PMC Article
    5. CFP-1 interacts with HDAC1/2 complexes in C. elegans development. Pokhrel B, et al. FEBS J, 2019 Jul. PMID 30941832

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Post-transcriptional repression of CFP-1 expands the regulatory repertoire of LIN-41/TRIM71.
      Title: Post-transcriptional repression of CFP-1 expands the regulatory repertoire of LIN-41/TRIM71.
    2. CFP-1 is required for fertility and normal growth rate. CFP-1 genetically interacts with HDAC1/2.
      Title: CFP-1 interacts with HDAC1/2 complexes in C. elegans development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transdifferentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CXXC-type zinc finger protein 1
    NP_001255784.1
    • Confirmed by transcript evidence
    NP_001255785.1
    • Confirmed by transcript evidence
    NP_001367055.1
    • Confirmed by transcript evidence
    NP_001367237.1
    • Confirmed by transcript evidence
    NP_001367271.1
    • Confirmed by transcript evidence
    NP_001367272.1
    • Confirmed by transcript evidence
    NP_001379228.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14077441..14083559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392439.1 → NP_001379228.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3YT77, E3W754, E3W755, E3W756, E3W757, Q86D13, Q9XUE7
      Conserved Domains (1) summary
      pfam12269
      Location:188 → 435
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

    2. NM_001380528.2 → NP_001367055.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam12269
      Location:69 → 316
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

    3. NM_001380529.1 → NP_001367271.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam12269
      Location:120 → 367
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

    4. NM_001380530.1 → NP_001367237.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam12269
      Location:1 → 248
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

    5. NM_001380531.1 → NP_001367272.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam12269
      Location:2 → 125
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

    6. NM_001268855.3 → NP_001255784.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3W756
      Conserved Domains (1) summary
      pfam12269
      Location:1 → 25
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

    7. NM_001268856.3 → NP_001255785.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3W757
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XUE7.3

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