Ddx51 DEAD box helicase 51 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddx51provided by MGI
Official Full Name: DEAD box helicase 51provided by MGI
Primary source: MGI:MGI:1916913
See related: Ensembl:ENSMUSG00000029504 AllianceGenome:MGI:1916913
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310061O04Rik
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Predicted to be involved in chromatin looping; chromatin remodeling; and rRNA processing. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human DDX51 (DEAD-box helicase 51). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 7.5), CNS E11.5 (RPKM 7.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.69 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (110801298..110810885)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (110653432..110663019)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mammalian DEAD box helicase family member Ddx51 is identified as a novel ribosome synthesis factor and an interacting partner of the nucleolar GTP-binding protein Nog1.
Title: Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125250 (e-PCR)
- UniSTS:162072

RH124509 (e-PCR)
- UniSTS:161331

R75505 (e-PCR)
- UniSTS:159416

C81583 (e-PCR)
- UniSTS:159418

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DDX51

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 51; DEAD box protein 51

NP_081432.2

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027156.3 → NP_081432.2 ATP-dependent RNA helicase DDX51

See identical proteins and their annotated locations for NP_081432.2

Status: VALIDATED

Source sequence(s)

BC060646, BY010157

Consensus CDS

CCDS19528.1

UniProtKB/Swiss-Prot

Q3U7M2, Q6P9R1

Related

ENSMUSP00000031478.6, ENSMUST00000031478.6

Conserved Domains (3) summary

PRK11192
Location:176 → 639

PRK11192; ATP-dependent RNA helicase SrmB; Provisional

pfam00271
Location:462 → 573

Helicase_C; Helicase conserved C-terminal domain

cl21455
Location:176 → 421

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases