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    TICAM1 TIR domain containing adaptor molecule 1 [ Homo sapiens (human) ]

    Gene ID: 148022, updated on 4-Jan-2025

    Summary

    Official Symbol
    TICAM1provided by HGNC
    Official Full Name
    TIR domain containing adaptor molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:18348
    See related
    Ensembl:ENSG00000127666 MIM:607601; AllianceGenome:HGNC:18348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
    Summary
    This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in esophagus (RPKM 10.4), duodenum (RPKM 6.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TICAM1 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4815932..4831712, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4801397..4817189, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4815944..4831724, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4791399-4792056 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4792057-4792713 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4792714-4793370 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:4804346-4804507 Neighboring gene fem-1 homolog A Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:4812531-4813730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9908 Neighboring gene perilipin 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4866939-4867439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9909 Neighboring gene CRISPRi-validated cis-regulatory element chr19.1096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4877563-4878446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4878447-4879328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4887083-4888076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4890817-4891318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4891319-4891818 Neighboring gene arrestin domain containing 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4908546-4909452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13788 Neighboring gene ubiquitin like with PHD and ring finger domains 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (18 hits/1269 screens)

    Associated conditions

    Description Tests
    Herpes simplex encephalitis, susceptibility to, 4
    MedGen: C3553869 OMIM: 614850 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC35334

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular adaptor activity PubMed 
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables signaling adaptor activity  
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in B cell proliferation  
    involved_in TRIF-dependent toll-like receptor signaling pathway  
    involved_in TRIF-dependent toll-like receptor signaling pathway PubMed 
    involved_in TRIF-dependent toll-like receptor signaling pathway  
    involved_in apoptotic signaling pathway  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus  
    involved_in defense response to virus  
    involved_in inflammatory response  
    involved_in innate immune response  
    involved_in lipopolysaccharide-mediated signaling pathway  
    involved_in macrophage activation involved in immune response  
    involved_in nitric oxide biosynthetic process  
    involved_in positive regulation of B cell proliferation  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of interferon-beta production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of macrophage cytokine production  
    involved_in positive regulation of myeloid dendritic cell cytokine production  
    involved_in positive regulation of natural killer cell activation  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of protein ubiquitination  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type I interferon production  
    involved_in positive regulation of type I interferon production PubMed 
    involved_in regulation of protein-containing complex assembly  
    acts_upstream_of_or_within response to exogenous dsRNA PubMed 
    involved_in response to exogenous dsRNA  
    involved_in toll-like receptor 3 signaling pathway PubMed 
    involved_in toll-like receptor 4 signaling pathway PubMed 
    involved_in toll-like receptor signaling pathway PubMed 
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    located_in autophagosome  
    located_in cytosol  
    is_active_in early endosome PubMed 
    is_active_in endosome  
    is_active_in endosome PubMed 
    is_active_in endosome membrane PubMed 
    located_in endosome membrane  
    located_in mitochondrion  
    part_of ripoptosome PubMed 

    General protein information

    Preferred Names
    TIR domain-containing adapter molecule 1
    Names
    TIR domain containing adaptor inducing interferon-beta
    TIR domain-containing adapter protein inducing IFN-beta
    proline-rich, vinculin and TIR domain-containing protein B
    putative NF-kappa-B-activating protein 502H
    toll like receptor adaptor molecule 1
    toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031998.1 RefSeqGene

      Range
      5001..20819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_358

    mRNA and Protein(s)

    1. NM_001385678.1 → NP_001372607.1  TIR domain-containing adapter molecule 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC027319
      Conserved Domains (3) summary
      pfam12721
      Location:642 → 683
      RHIM; RIP homotypic interaction motif
      pfam17798
      Location:3 → 134
      TRIF-NTD; TRIF N-terminal domain
      cl23749
      Location:385 → 513
      TIR_2; TIR domain
    2. NM_001385679.1 → NP_001372608.1  TIR domain-containing adapter molecule 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC027319
      Conserved Domains (3) summary
      pfam12721
      Location:611 → 652
      RHIM; RIP homotypic interaction motif
      pfam17798
      Location:1 → 103
      TRIF-NTD; TRIF N-terminal domain
      cl23749
      Location:354 → 482
      TIR_2; TIR domain
    3. NM_001385680.1 → NP_001372609.1  TIR domain-containing adapter molecule 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC027319
      Conserved Domains (2) summary
      pfam12721
      Location:446 → 483
      RHIM; RIP homotypic interaction motif
      cl23749
      Location:185 → 313
      TIR_2; TIR domain
    4. NM_182919.4 → NP_891549.1  TIR domain-containing adapter molecule 1 isoform 1

      See identical proteins and their annotated locations for NP_891549.1

      Status: REVIEWED

      Source sequence(s)
      AB086380, BC035331, BX349282, DR000002
      Consensus CDS
      CCDS12136.1
      UniProtKB/Swiss-Prot
      B3Y691, O75532, Q86XP8, Q8IUC6, Q96GA0
      Related
      ENSP00000248244.4, ENST00000248244.6
      Conserved Domains (2) summary
      pfam12721
      Location:654 → 696
      RHIM; RIP homotypic interaction motif
      cl23749
      Location:399 → 527
      TIR_2; TIR domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      4815932..4831712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      4801397..4817189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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