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    HMLALPHA2 homeodomain mating type protein alpha2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HMLALPHA2
    Official Full Name
    homeodomain mating type protein alpha2
    Primary source
    SGD:S000000572
    Locus tag
    YCL067C
    See related
    AllianceGenome:SGD:S000000572; FungiDB:YCL067C; VEuPathDB:YCL067C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ALPHA2
    Summary
    Predicted to enable DNA binding activity, bending; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in mating type determination and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HMLALPHA2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (12386..13018, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene basic amino acid transporter Neighboring gene uncharacterized protein Neighboring gene transcriptional co-activator mating type protein alpha Neighboring gene L-serine/L-threonine ammonia-lyase CHA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mating type control in Saccharomyces cerevisiae: a frameshift mutation at the common DNA sequence, X, of the HML alpha locus. Tanaka K, et al. Mol Cell Biol, 1984 Jan. PMID 6321951, Free PMC Article
    2. Mating-type gene switching in Saccharomyces cerevisiae. Haber JE. Annu Rev Genet, 1998. PMID 9928492
    3. Cell type-specific chromatin organization of the region that governs directionality of yeast mating type switching. Weiss K, et al. EMBO J, 1997 Jul 16. PMID 9250679, Free PMC Article
    4. The mating-type proteins of fission yeast induce meiosis by directly activating mei3 transcription. Van Heeckeren WJ, et al. Mol Cell Biol, 1998 Dec. PMID 9819418, Free PMC Article
    5. Identification and comparison of two sequence elements that confer cell-type specific transcription in yeast. Miller AM, et al. Nature, 1985 Apr 18-24. PMID 3887184

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding, bending ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mating type determination ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeodomain mating type protein alpha2
    NP_009866.1
    • Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      12386..13018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178708.1 → NP_009866.1  TPA: homeodomain mating type protein alpha2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQV2, P01367, P01368, P0CY08, P0CY09, Q6B2C0
      UniProtKB/TrEMBL
      A6ZTM1, B3LU20, C8Z424, G2WA57
      Conserved Domains (1) summary
      smart00389
      Location:135 → 188
      HOX; Homeodomain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CY08.1
    P0CY09.1

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