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    Rptor regulatory associated protein of MTOR, complex 1 [ Mus musculus (house mouse) ]

    Gene ID: 74370, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rptorprovided by MGI
    Official Full Name
    regulatory associated protein of MTOR, complex 1provided by MGI
    Primary source
    MGI:MGI:1921620
    See related
    Ensembl:ENSMUSG00000025583 AllianceGenome:MGI:1921620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rap; Raptor; mKIAA1303; 4932417H02Rik
    Summary
    This gene encodes a subunit of mammalian target of rapamycin complex 1 (mTORC1), a component of the mTOR signaling pathway, which regulates cell growth in response to nutrient and energy levels. The encoded protein may regulate the assembly, localization, and substrate binding of the mTORC1 complex. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 14.6), thymus adult (RPKM 13.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rptor in Genome Data Viewer
    Location:
    11 E2; 11 83.96 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119493731..119790417)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119602905..119899591)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31323 Neighboring gene predicted gene 11762 Neighboring gene neuronal pentraxin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:119464137-119464320 Neighboring gene STARR-seq mESC enhancer starr_31326 Neighboring gene STARR-seq mESC enhancer starr_31328 Neighboring gene STARR-seq mESC enhancer starr_31330 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:119695611-119695882 Neighboring gene regulatory associated protein of MTOR, complex 1, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:119718261-119718370 Neighboring gene STARR-positive B cell enhancer ABC_E10735 Neighboring gene STARR-seq mESC enhancer starr_31337 Neighboring gene STARR-positive B cell enhancer ABC_E2379 Neighboring gene predicted gene, 39485 Neighboring gene charged multivesicular body protein 6 Neighboring gene predicted gene 11767

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hypoxia NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nutrient levels NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to osmotic stress NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of autophagy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycolytic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of lipid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of odontoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of pentose-phosphate shunt NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of TORC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of TORC1 complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of TORC1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    regulatory-associated protein of mTOR
    Names
    p150 target of rapamycin (TOR)-scaffold protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306081.1NP_001293010.1  regulatory-associated protein of mTOR isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK144082, AK161011, BC060140
      Conserved Domains (6) summary
      COG2319
      Location:598911
      WD40; WD40 repeat [General function prediction only]
      cd00020
      Location:181250
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:145247
      HEAT_2; HEAT repeats
      sd00044
      Location:95123
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:606642
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:606901
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_028898.3NP_083174.2  regulatory-associated protein of mTOR isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK144082, AK161011, BC060140, BC118971
      Consensus CDS
      CCDS25720.1
      UniProtKB/Swiss-Prot
      Q8C9W9, Q8CBY4, Q8CDY8, Q8K4Q0, Q9D4H3
      UniProtKB/TrEMBL
      A2ACM0
      Related
      ENSMUSP00000026671.7, ENSMUST00000026671.13
      Conserved Domains (7) summary
      COG2319
      Location:10191332
      WD40; WD40 repeat [General function prediction only]
      cd00020
      Location:602671
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:566668
      HEAT_2; HEAT repeats
      pfam14538
      Location:60206
      Raptor_N; Raptor N-terminal CASPase like domain
      sd00044
      Location:516544
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:10271063
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:10271322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      119493731..119790417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534363.4XP_006534426.1  regulatory-associated protein of mTOR isoform X3

      UniProtKB/Swiss-Prot
      Q8C9W9, Q8CBY4, Q8CDY8, Q8K4Q0, Q9D4H3
      Conserved Domains (6) summary
      COG5096
      Location:390614
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:434462
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:945981
      7WD40; WD40 repeat [structural motif]
      pfam14538
      Location:55206
      Raptor_N; Raptor N-terminal CASPase like domain
      pfam13646
      Location:484586
      HEAT_2; HEAT repeats
      cl29593
      Location:9451240
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006534361.5XP_006534424.1  regulatory-associated protein of mTOR isoform X1

      UniProtKB/Swiss-Prot
      Q8C9W9, Q8CBY4, Q8CDY8, Q8K4Q0, Q9D4H3
      Conserved Domains (6) summary
      COG5096
      Location:452676
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:496524
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:10071043
      7WD40; WD40 repeat [structural motif]
      pfam14538
      Location:55206
      Raptor_N; Raptor N-terminal CASPase like domain
      pfam13646
      Location:546648
      HEAT_2; HEAT repeats
      cl29593
      Location:10071302
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006534362.1XP_006534425.1  regulatory-associated protein of mTOR isoform X2

      UniProtKB/TrEMBL
      A4FUW1
      Conserved Domains (6) summary
      COG5096
      Location:418642
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:462490
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:9731009
      7WD40; WD40 repeat [structural motif]
      pfam14538
      Location:1152
      Raptor_N; Raptor N-terminal CASPase like domain
      pfam13646
      Location:512614
      HEAT_2; HEAT repeats
      cl29593
      Location:9731268
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_036157047.1XP_036012940.1  regulatory-associated protein of mTOR isoform X4

      UniProtKB/TrEMBL
      A4FUW1
      Conserved Domains (6) summary
      COG5096
      Location:324548
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:368396
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:879915
      7WD40; WD40 repeat [structural motif]
      pfam13646
      Location:418520
      HEAT_2; HEAT repeats
      pfam14538
      Location:858
      Raptor_N; Raptor N-terminal CASPase like domain
      cl29593
      Location:8791174
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_011249286.4XP_011247588.1  regulatory-associated protein of mTOR isoform X5

      Conserved Domains (4) summary
      sd00044
      Location:3766
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:501537
      7WD40; WD40 repeat [structural motif]
      pfam13646
      Location:40142
      HEAT_2; HEAT repeats
      cl29593
      Location:501796
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. XM_030246393.2XP_030102253.1  regulatory-associated protein of mTOR isoform X5

      Conserved Domains (4) summary
      sd00044
      Location:3766
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:501537
      7WD40; WD40 repeat [structural motif]
      pfam13646
      Location:40142
      HEAT_2; HEAT repeats
      cl29593
      Location:501796
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...