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    RPS3A ribosomal protein S3A [ Homo sapiens (human) ]

    Gene ID: 6189, updated on 9-Dec-2024

    Summary

    Official Symbol
    RPS3Aprovided by HGNC
    Official Full Name
    ribosomal protein S3Aprovided by HGNC
    Primary source
    HGNC:HGNC:10421
    See related
    Ensembl:ENSG00000145425 MIM:180478; AllianceGenome:HGNC:10421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S3A; eS1; FTE1; MFTL
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 854.6), bone marrow (RPKM 571.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPS3A in Genome Data Viewer
    Location:
    4q31.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (151099628..151104642)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (154423512..154428526)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (152020780..152025794)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene LPS responsive beige-like anchor protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:151908831-151909345 Neighboring gene LRBA intron ENCODE-defined enhancer Neighboring gene RNA, 5S ribosomal pseudogene 168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22017 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:151936707-151937304 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22019 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:152020037-152021236 Neighboring gene uncharacterized LOC107986196 Neighboring gene adenylate kinase 4 pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 3738 Neighboring gene small nucleolar RNA, C/D box U73B Neighboring gene small nucleolar RNA, C/D box 73A Neighboring gene uncharacterized LOC105377485 Neighboring gene SH3 domain containing 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, ribosomal protein S3A (RPS3A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human ribosomal protein S3A (RPS3A) at amino acid residues 66-67 and 69-70 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC23240

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translational initiation TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    small ribosomal subunit protein eS1
    Names
    40S ribosomal protein S3a
    fte-1
    v-fos transformation effector protein 1
    NP_000997.1
    NP_001254628.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006.5NP_000997.1  small ribosomal subunit protein eS1 isoform 1

      See identical proteins and their annotated locations for NP_000997.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC001708, CA441711
      Consensus CDS
      CCDS3775.1
      UniProtKB/Swiss-Prot
      B2R4D4, D3DP05, P33443, P49241, P61247
      UniProtKB/TrEMBL
      A8K4W0, Q6NXR8
      Related
      ENSP00000346050.3, ENST00000274065.9
      Conserved Domains (1) summary
      pfam01015
      Location:21221
      Ribosomal_S3Ae; Ribosomal S3Ae family
    2. NM_001267699.2NP_001254628.1  small ribosomal subunit protein eS1 isoform 2

      See identical proteins and their annotated locations for NP_001254628.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal coding exon and differs at the 3' end compared to variant 1, which results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI038646, AK296121, AK308947, CN315189
      UniProtKB/TrEMBL
      B7Z3M5
      Related
      ENST00000507485.1
      Conserved Domains (1) summary
      cl00821
      Location:2150
      Ribosomal_S3Ae; Ribosomal S3Ae family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      151099628..151104642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791772.1 Reference GRCh38.p14 PATCHES

      Range
      36359..41373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      154423512..154428526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)