HSPE1 heat shock protein family E (Hsp10) member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSPE1provided by HGNC
Official Full Name: heat shock protein family E (Hsp10) member 1provided by HGNC
Primary source: HGNC:HGNC:5269
See related: Ensembl:ENSG00000115541 MIM:600141; AllianceGenome:HGNC:5269
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EPF; CPN10; GROES; HSP10
Summary: This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]
Expression: Ubiquitous expression in adrenal (RPKM 184.7), kidney (RPKM 90.5) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q33.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (197500379..197503449)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (197983980..197987052)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (198365103..198368173)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60.
Title: Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60.
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
Title: Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space.
Title: An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space.
structural basis for active single- and double-ring complexes coexisting in the mHsp60-mHsp10 chaperonin reaction cycle
Title: Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin.
elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma
Title: Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.
miR-146a, miR-146b, and miR-155 are exerting anti-inflammatory properties by down-regulating IL-6 and IL-8, and influencing the expression of HSP10 in the activated endothelium
Title: miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model.
High expression of HSP10 is negatively associated with estrogen receptor/progesterone receptor status and might be a novel independent biomarker for poor prognosis in invasive ductal breast carcinoma.
Title: High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.
EPF induces the differentiation of regulatory T cells and increases their immunosuppressive activities.
Title: Early Pregnancy Factor Enhances the Generation and Function of CD4(+)CD25(+) Regulatory T Cells.
Hsp10 and Hsp60 may be implicated in carcinogenesis from its very early steps in colorectal cancer.
Title: Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Data indicate that on addition of the heat-shock proteins GroEL-GroES molecular chaperone system, the folding of the nascent chemokine receptor type 5 (CCR5) was significantly enhanced.
Title: Folding of newly translated membrane protein CCR5 is assisted by the chaperonin GroEL-GroES.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of heat shock 10kDa protein 1 (HSPE1; HSP10) in Jurkat cells	PubMed
integrase	gag-pol	HSP10 interacts with HIV-1 integrase, which is a substrate for the hHSP60-HSP10 complex	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15S1344 (e-PCR)
- UniSTS:38412

D12S1803 (e-PCR)
- UniSTS:154603

Readthrough HSPE1-MOB4

Readthrough gene: HSPE1-MOB4, Included gene: MOB4

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in osteoblast differentiation	HDA more info	PubMed
involved_in protein folding	TAS Traceable Author Statement more info	PubMed
involved_in response to unfolded protein	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 10 kDa heat shock protein, mitochondrial

Names: 10 kDa chaperonin; chaperonin 10; early-pregnancy factor; epididymis secretory sperm binding protein; heat shock 10kD protein 1 (chaperonin 10); heat shock 10kDa protein 1; heat shock protein family E member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008914.1 RefSeqGene

Range

5383..8453

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002157.3 → NP_002148.1 10 kDa heat shock protein, mitochondrial

See identical proteins and their annotated locations for NP_002148.1

Status: REVIEWED

Source sequence(s)

BC023518, BG188453

Consensus CDS

CCDS2320.1

UniProtKB/Swiss-Prot

O95421, P61604, Q04984, Q53X54, Q9UDH0

UniProtKB/TrEMBL

A0A384N6A4, Q9UNM1

Related

ENSP00000233893.5, ENST00000233893.10

Conserved Domains (1) summary

cd00320
Location:8 → 100

cpn10; Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It ...