SNF4 AMP-activated serine/threonine-protein kinase regulatory subunit SNF4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SNF4
Official Full Name: AMP-activated serine/threonine-protein kinase regulatory subunit SNF4
Primary source: SGD:S000003083
Locus tag: YGL115W
See related: AllianceGenome:SGD:S000003083; FungiDB:YGL115W; VEuPathDB:YGL115W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CAT3; SCI1
Summary: Enables protein serine/threonine kinase activator activity. Contributes to AMP-activated protein kinase activity. Involved in several processes, including peroxisome organization; positive regulation of gluconeogenesis; and regulation of transcription by RNA polymerase II. Located in cytoplasm; nuclear envelope lumen; and plasma membrane. Part of nucleotide-activated protein kinase complex. Used to study Wolff-Parkinson-White syndrome and lethal congenital glycogen storage disease of heart. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to several human genes including PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SNF4 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (292033..293001)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase
Title: Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase.
We report here the crystal structure at 1.9 Angstrom resolution of the Bateman2 domain of Snf4, the gamma subunit of the yeast ortholog of AMPK.
Title: Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to AMP-activated protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to AMP-activated protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gluconeogenesis	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of carbon utilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in nuclear envelope lumen	IDA Inferred from Direct Assay more info	PubMed
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of nucleotide-activated protein kinase complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: AMP-activated serine/threonine-protein kinase regulatory subunit SNF4

NP_011400.1

Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

292033..293001

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180980.1 → NP_011400.1 TPA: AMP-activated serine/threonine-protein kinase regulatory subunit SNF4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011400.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VU32, P12904

UniProtKB/TrEMBL

A6ZU66, B3LHH7, B5VIL2, C7GM09, C8Z8D5, F4ZZV2, G2WDY6, N1P5D4

Conserved Domains (2) summary

cd04618
Location:30 → 172

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:195 → 318

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase