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    Cr1l complement C3b/C4b receptor 1 like [ Mus musculus (house mouse) ]

    Gene ID: 12946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cr1lprovided by MGI
    Official Full Name
    complement C3b/C4b receptor 1 likeprovided by MGI
    Primary source
    MGI:MGI:88513
    See related
    Ensembl:ENSMUSG00000016481 AllianceGenome:MGI:88513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcp; Crry; mCRY
    Summary
    Predicted to enable complement receptor activity and opsonin binding activity. Acts upstream of or within several processes, including cellular response to hypoxia; complement activation; and negative regulation of complement activation. Located in basolateral plasma membrane and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in malaria. Orthologous to several human genes including CR1L (complement C3b/C4b receptor 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 23.9), placenta adult (RPKM 23.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cr1l in Genome Data Viewer
    Location:
    1 H6; 1 98.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194781019..194813878, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (195098711..195131570, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330023F24 gene Neighboring gene microRNA 29b-2 Neighboring gene STARR-seq mESC enhancer starr_03503 Neighboring gene microRNA 29c Neighboring gene CD46 antigen, complement regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E11117 Neighboring gene STARR-seq mESC enhancer starr_03504 Neighboring gene predicted gene, 32313 Neighboring gene complement receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E11118 Neighboring gene predicted gene, 29726

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The murine complement regulator Crry: new insights into the immunobiology of complement regulation. Molina H. Cell Mol Life Sci, 2002 Feb. PMID 11915940, Free PMC Article
    2. Cutting edge: treatment of complement regulatory protein deficiency by retroviral in vivo gene therapy. Spitzer D, et al. J Immunol, 2006 Oct 15. PMID 17015675
    3. Astrocyte-specific expression of a soluble form of the murine complement control protein Crry confers demyelination protection in the cuprizone model. Briggs DT, et al. Glia, 2007 Nov 1. PMID 17674370
    4. Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion. Thurman JM, et al. J Clin Invest, 2006 Feb. PMID 16444293, Free PMC Article
    5. In vivo correction of complement regulatory protein deficiency with an inhibitor targeting the red blood cell membrane. Spitzer D, et al. J Immunol, 2005 Dec 1. PMID 16301687

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction.
      Title: Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction.
    2. Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones.
      Title: Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones.
    3. Our study uncovers a damaging effect of complement C3 or downstream complement activation in glaucoma, and it establishes AAV2.CR2-Crry as a viable therapeutic strategy to target pathogenic C3-mediated complement activation in the glaucomatous retina
      Title: Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma.
    4. CRRY role in the retinal epithelium and photoreceptor degeneration
      Title: Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.
    5. Factor H and Crry are critical for regulating complement activation at distinct anatomic sites within the kidney.
      Title: Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.
    6. this study has provided direct evidence for a role of Crry in controlling spontaneous alternative pathway complement activation on renal tubular epithelial cells.
      Title: Tissue-specific deletion of Crry from mouse proximal tubular epithelial cells increases susceptibility to renal ischemia-reperfusion injury.
    7. HBx can up-regulate CD59 and Crry expression in podocytes through activating the P38 pathway.
      Title: [Hepatitis B virus X protein upregulates the expression of CD59 and Crry in mouse podocytes].
    8. Crry costimulation enhanced the in vitro expansion of natural Treg cells while maintaining their phenotypic and suppressive properties. Crry-expanded Treg cells decreasing antigen-dependent secretion of cytokines.
      Title: Complement regulatory protein Crry/p65 costimulation expands natural treg cells with enhanced suppressive properties in proteoglycan-induced arthritis.
    9. Stmn2 and the chromosome 14 Rarb region, but not Cr1 or Clu or Picalm, have roles in prion disease.
      Title: The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.
    10. There is a significant reduction in the numbers of both neutrophils and macrophages in cardiac isografts isolated from mice treated with either complement receptor 2-Crry or CR2-factor H.
      Title: Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102484

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables complement component C3b binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables complement component C3b receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables complement component C4b binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables complement component C4b receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within complement activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of complement activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of complement activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of complement activation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement component receptor 1-like protein
    Names
    complement component (3b/4b) receptor 1-like
    complement receptor related protein
    complement regulatory protein Crry
    protein p65

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355060.1 → NP_001341989.1  complement component receptor 1-like protein isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC139206, AK134226
      Consensus CDS
      CCDS87948.1
      UniProtKB/Swiss-Prot
      E9QL18, Q3TV30, Q58E68, Q61447, Q61449, Q64735, Q8CF59, Q8K328
      UniProtKB/TrEMBL
      A0A0A6YY75
      Related
      ENSMUSP00000142309.2, ENSMUST00000193094.6
      Conserved Domains (1) summary
      cl27761
      Location:42 → 295
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    2. NM_001355061.1 → NP_001341990.1  complement component receptor 1-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139206, AK160440
      Consensus CDS
      CCDS87947.1
      UniProtKB/TrEMBL
      A0A0A6YXN9
      Related
      ENSMUSP00000142069.2, ENSMUST00000194111.6
      Conserved Domains (1) summary
      cl27761
      Location:4 → 257
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    3. NM_013499.2 → NP_038527.2  complement component receptor 1-like protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_038527.2

      Status: VALIDATED

      Source sequence(s)
      AI098173, AK004825, CA491482
      Consensus CDS
      CCDS15641.1
      UniProtKB/Swiss-Prot
      E9QL18, Q3TV30, Q58E68, Q61447, Q61449, Q64735, Q8CF59, Q8K328
      Related
      ENSMUSP00000074902.7, ENSMUST00000075451.12
      Conserved Domains (4) summary
      cd00033
      Location:165 → 232
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:237 → 293
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:42 → 295
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:42 → 98
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      194781019..194813878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64735.1 GenPept UniProtKB/Swiss-Prot:Q64735

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