KAP104 Kap104p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: KAP104
Official Full Name: Kap104p
Primary source: SGD:S000000221
Locus tag: YBR017C
See related: AllianceGenome:SGD:S000000221; FungiDB:YBR017C; VEuPathDB:YBR017C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables nuclear localization sequence binding activity. Involved in exit from mitosis and protein import into nucleus. Located in cellular bud neck; cellular bud tip; and cytosol. Human ortholog(s) of this gene implicated in intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. Orthologous to several human genes including TNPO2 (transportin 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See KAP104 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (270947..273703, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data hypothesize on a possible function of Kap104p in the localized protein synthesis.
Title: A karyopherin acts in localized protein synthesis.
Temporally and spatially coordinated localization of Kap104p is a new mechanism for the asymmetric distribution of protein synthesis in dividing cells.
Title: Nuclear transport factor directs localization of protein synthesis during mitosis.
identified three Proline-tyrosine nuclear localization signals regions that are important for binding Kap104p
Title: Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals.
The Kap104p supports import for nuclear uptake of H3 and H4.
Title: The histones H2A/H2B and H3/H4 are imported into the yeast nucleus by different mechanisms.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Kap104p

NP_009573.1

Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

270947..273703 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178365.1 → NP_009573.1 TPA: Kap104p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009573.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQ19, P38217

UniProtKB/TrEMBL

B3LNC4, B5VDY6, N1P7Y5

Conserved Domains (3) summary

pfam13513
Location:435 → 489

HEAT_EZ; HEAT-like repeat

pfam13646
Location:424 → 528

HEAT_2; HEAT repeats

sd00044
Location:422 → 450

HEAT; HEAT repeat [structural motif]