NFATC2 nuclear factor of activated T cells 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NFATC2provided by HGNC
Official Full Name: nuclear factor of activated T cells 2provided by HGNC
Primary source: HGNC:HGNC:7776
See related: Ensembl:ENSG00000101096 MIM:600490; AllianceGenome:HGNC:7776
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JCOSL; NFAT1; NFATP
Summary: This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
Expression: Broad expression in gall bladder (RPKM 9.1), lymph node (RPKM 6.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (51386963..51562839, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (53157543..53333581, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (50003500..50179378, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration.
Title: STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration.
The Dual Role of the NFATc2/galectin-9 Axis in Modulating Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma.
Title: The Dual Role of the NFATc2/galectin-9 Axis in Modulating Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma.
The RNA m[6]A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer.
Title: The RNA m(6)A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer.
Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma.
Title: Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma.
Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.
Title: Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.
Effect of NFATc2- and Sp1-mediated TNFalpha Regulation on the Proliferation and Migration Behavior of Pancreatic Cancer Cells.
Title: Effect of NFATc2- and Sp1-mediated TNFalpha Regulation on the Proliferation and Migration Behavior of Pancreatic Cancer Cells.
Over-expression of cFos by the Transcription Factors NFATc2 and Sp1 in Pancreatic Cancer Cells.
Title: Over-expression of cFos by the Transcription Factors NFATc2 and Sp1 in Pancreatic Cancer Cells.
NFAT1 and NFkappaB regulates expression of the common gamma-chain cytokine receptor in activated T cells.
Title: NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells.
Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma.
Title: Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma.
Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.
Title: Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.

Submit: New GeneRIF Correction See all GeneRIFs (158)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Joint contractures, osteochondromas, and B-cell lymphoma MedGen: C5774305 OMIM: 620232 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH). EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation	PubMed
	env	Using either anti-CD4 monoclonal antibodies or HIV-1 gp120 binding to CD4 reveals a common epitope-specific activation of both the HIV-1 LTR and of the transcription factors NF-kappa B and NF-AT	PubMed
Nef	nef	HIV-1 Vpu downregulates NRON levels but HIV-1 Nef upregulates NRON levels in Jurkat cells, leading to reciprocal regulation in NFAT activity through NRON by Vpu and Nef	PubMed
	nef	The induction of NFAT1 and NFAT2 is impaired by HIV-1 Nef in sub-optimally activated/resting T cells	PubMed
	nef	HIV-1 Nef super induces the transcription factors NFAT1 and NFAT2 during activation of HIV-infected quiescent T cells	PubMed
Tat	tat	The transcription factors NF-KappaB and NF-AT contribute to the Tat-induced activation of the HERV-K (HML-2) gag RNA transcripts in Jurkat T cells and in primary lymphocytes	PubMed
	tat	Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2	PubMed
	tat	HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR	PubMed
	tat	NFAT1 inhibits Tat-mediated transactivation of the HIV-1 LTR promoter through a direct binding interaction between the two proteins	PubMed
	tat	HIV-1 Tat enhances NFAT1-driven transcription in Jurkat T cells through a direct protein-protein interaction between the two proteins	PubMed
	tat	Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT	PubMed
	tat	HIV-1 Tat upregulation of the IL-2 promoter maps to the NFAT motif of the IL-2 enhancer, suggesting Tat-mediated enhancement of NFAT1 transactivation may explain the upregulation of IL-2 that occurs during HIV-1 infection	PubMed
	tat	HIV-1 Tat binds to NFAT1, an interaction mediated by the N-terminus of Tat (amino acids 1-26) and the transactivation domain of NFAT1 (amino acids 1-96)	PubMed
Vpr	vpr	HIV-1 Vpr upregulates NFAT-directed gene expression	PubMed
Vpu	vpu	HIV-1 Vpu downregulates NRON levels but HIV-1 Nef upregulates NRON levels in Jurkat cells, leading to reciprocal regulation in NFAT activity through NRON by Vpu and Nef	PubMed
reverse transcriptase	gag-pol	NFATc facilitates HIV-1 RT reverse transcription activity and enhances HIV-1 infectivity in human T cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20S857 (e-PCR), detects polymorphism
- UniSTS:54045

RH36387 (e-PCR)
- UniSTS:2606

AL032542 (e-PCR)
- UniSTS:93288

SHGC-144024 (e-PCR)
- UniSTS:172138

SHGC-85834 (e-PCR)
- UniSTS:103835

STS-M78243 (e-PCR)
- UniSTS:36816

RH38986 (e-PCR)
- UniSTS:91092

D20S128E (e-PCR)
- UniSTS:78049

GDB:555597 (e-PCR)
- UniSTS:157689

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	EXP Inferred from Experiment more info	PubMed
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in lncRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in myotube cell development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor AP-1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear factor of activated T-cells, cytoplasmic 2

Names: NF-ATc2; NFAT pre-existing subunit; NFAT transcription complex, preexisting component; T cell transcription factor NFAT1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, preexisting component; preexisting nuclear factor of activated T-cells 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136021.3 → NP_001129493.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform D

See identical proteins and their annotated locations for NP_001129493.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate first exon and contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (D) has shorter and distinct N- and C-termini compared to isoform C.

Source sequence(s)

AK226146, AL035682, AL035684, BE674599, EU887574

Consensus CDS

CCDS46614.1

UniProtKB/Swiss-Prot

Q13469

Related

ENSP00000396471.1, ENST00000414705.5

Conserved Domains (2) summary

cd07881
Location:378 → 552

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:557 → 657

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001258292.2 → NP_001245221.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform E

See identical proteins and their annotated locations for NP_001245221.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate first exon compared to variant 2. The resulting isoform (E) has a shorter and distinct N-terminus compared to isoform C.

Source sequence(s)

AK226146, AL035682, AL035684, BE674599

Consensus CDS

CCDS68157.1

UniProtKB/Swiss-Prot

Q13469

Related

ENSP00000477370.1, ENST00000609943.5

Conserved Domains (2) summary

cd07881
Location:378 → 552

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:557 → 657

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001258294.2 → NP_001245223.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform F

See identical proteins and their annotated locations for NP_001245223.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate first exon, an alternate exon in the 3' end, and uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (F) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform C. Variants 5 and 7 both encode the same isoform (F).

Source sequence(s)

AL035682, AL035684, BE674599, EU887575

Consensus CDS

CCDS68156.1

UniProtKB/Swiss-Prot

Q13469

Related

ENSP00000477342.1, ENST00000609507.1

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:358 → 458

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001258295.2 → NP_001245224.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform G

See identical proteins and their annotated locations for NP_001245224.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) has an alternate first exon and uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (G) is shorter at the N-terminus compared to isoform C. Variants 6 and 8 both encode the same isoform (G).

Source sequence(s)

AL035682, AL035684, BE674599, EU887579

UniProtKB/TrEMBL

B5B2P4

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:358 → 458

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001258296.2 → NP_001245225.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform F

See identical proteins and their annotated locations for NP_001245225.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate splice junction at the 5' end of a coding exon and contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (F) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform C. Variants 5 and 7 both encode the same isoform (F).

Source sequence(s)

AL035682, BE674599, EU887576

Consensus CDS

CCDS68156.1

UniProtKB/Swiss-Prot

Q13469

Related

ENSP00000477142.1, ENST00000610033.5

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:358 → 458

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001258297.2 → NP_001245226.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform G

See identical proteins and their annotated locations for NP_001245226.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (G) is shorter at the N-terminus compared to isoform C. Variants 6 and 8 both encode the same isoform (G).

Source sequence(s)

AL035682, BE674599, EU887580

UniProtKB/TrEMBL

B5B2P4

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:358 → 458

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_012340.5 → NP_036472.2 nuclear factor of activated T-cells, cytoplasmic 2 isoform B

See identical proteins and their annotated locations for NP_036472.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (B) has a shorter and distinct C-terminus compared to isoform C.

Source sequence(s)

AL035682, BE674599, EU887573, EU887576

Consensus CDS

CCDS33488.1

UniProtKB/Swiss-Prot

Q13469

Related

ENSP00000360619.3, ENST00000371564.8

Conserved Domains (2) summary

cd07881
Location:398 → 572

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:577 → 677

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_173091.4 → NP_775114.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform C

See identical proteins and their annotated locations for NP_775114.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes the longest isoform (C).

Source sequence(s)

AL035682, BE674599, EU887576, EU887578

Consensus CDS

CCDS13437.1

UniProtKB/Swiss-Prot

B5B2N8, B5B2N9, B5B2P0, B5B2P2, B5B2P3, Q13468, Q13469, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2

Related

ENSP00000379330.3, ENST00000396009.7

Conserved Domains (2) summary

cd07881
Location:398 → 572

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:577 → 677

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

51386963..51562839 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017027851.2 → XP_016883340.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform X3
XM_011528826.3 → XP_011527128.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform X4

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:358 → 458

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_011528825.3 → XP_011527127.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform X2

Conserved Domains (2) summary

cd07881
Location:378 → 552

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:557 → 657

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_011528824.3 → XP_011527126.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform X1

Conserved Domains (2) summary

cd07881
Location:398 → 572

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:577 → 677

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

53157543..53333581 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054323454.1 → XP_054179429.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform X3
XM_054323455.1 → XP_054179430.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform X4
XM_054323453.1 → XP_054179428.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform X2
XM_054323452.1 → XP_054179427.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform X1