Fbf1 Fas binding factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbf1provided by MGI
Official Full Name: Fas binding factor 1provided by MGI
Primary source: MGI:MGI:1922033
See related: Ensembl:ENSMUSG00000020776 AllianceGenome:MGI:1922033
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1863; 5930413D20; 1110033G01Rik
Summary: Predicted to be involved in apical junction assembly; cilium assembly; and establishment of epithelial cell polarity. Located in centriole. Is expressed in cerebral cortex. Orthologous to human FBF1 (Fas binding factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 16.9), whole brain E14.5 (RPKM 16.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.93 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (116033111..116059097, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (116142285..116168271, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.
Title: FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.
Fbf1 regulates mouse oocyte meiosis by influencing Plk1.
Title: Fbf1 regulates mouse oocyte meiosis by influencing Plk1.
Albatross is a novel protein that spatiotemporally integrates different aspects of centrosome function, namely ciliogenesis, centriole duplication, and centrosome separation.
Title: Albatross/FBF1 contributes to both centriole duplication and centrosome separation.
Keratins and the keratin-binding protein Albatross are important for epithelial cell polarization.
Title: The keratin-binding protein Albatross regulates polarization of epithelial cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apical junction assembly	ISO Inferred from Sequence Orthology more info
involved_in apical junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell polarity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
colocalizes_with apical junction complex	ISO Inferred from Sequence Orthology more info
colocalizes_with apical junction complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
part_of ciliary transition fiber	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
colocalizes_with keratin filament	ISO Inferred from Sequence Orthology more info
colocalizes_with keratin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fas-binding factor 1

Names: FBF-1; Fas (TNFRSF6) binding factor 1; likely ortholog of H. sapiens Fas (TNFRSF6) binding factor 1 (FBF1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364077.1 → NP_001351006.1 fas-binding factor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL607108

Consensus CDS

CCDS25659.1

UniProtKB/Swiss-Prot

A2A870, A2A871, B2RQ77, Q8BSP0, Q99MZ9

Conserved Domains (2) summary

PHA03247
Location:69 → 530

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:602 → 1088

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
NM_001364078.1 → NP_001351007.1 fas-binding factor 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL607108

UniProtKB/TrEMBL

B7ZN01

Conserved Domains (2) summary

PHA03247
Location:69 → 529

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:601 → 1087

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
NM_001364079.1 → NP_001351008.1 fas-binding factor 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL607108, BC043126

Related

ENSMUST00000136318.8

Conserved Domains (2) summary

cl25732
Location:662 → 928

SMC_N; RecF/RecN/SMC N terminal domain

cl26464
Location:177 → 378

Atrophin-1; Atrophin-1 family
NM_172571.3 → NP_766159.3 fas-binding factor 1 isoform 1

See identical proteins and their annotated locations for NP_766159.3

Status: VALIDATED

Source sequence(s)

AK086991, BC043126, BC092220, BY794008

Consensus CDS

CCDS25659.1

UniProtKB/Swiss-Prot

A2A870, A2A871, B2RQ77, Q8BSP0, Q99MZ9

Conserved Domains (2) summary

PHA03247
Location:69 → 530

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:602 → 1088

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

116033111..116059097 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248948.3 → XP_011247250.1 fas-binding factor 1 isoform X1

See identical proteins and their annotated locations for XP_011247250.1

UniProtKB/Swiss-Prot

A2A870, A2A871, B2RQ77, Q8BSP0, Q99MZ9

Related

ENSMUSP00000102043.3, ENSMUST00000106435.9

Conserved Domains (2) summary

PHA03247
Location:69 → 530

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:602 → 1088

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_006533093.5 → XP_006533156.1 fas-binding factor 1 isoform X1

See identical proteins and their annotated locations for XP_006533156.1

UniProtKB/Swiss-Prot

A2A870, A2A871, B2RQ77, Q8BSP0, Q99MZ9

Conserved Domains (2) summary

PHA03247
Location:69 → 530

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:602 → 1088

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_036156607.1 → XP_036012500.1 fas-binding factor 1 isoform X2

UniProtKB/TrEMBL

B7ZN01

Conserved Domains (2) summary

PHA03247
Location:69 → 529

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:601 → 1087

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_006533092.5 → XP_006533155.1 fas-binding factor 1 isoform X1

See identical proteins and their annotated locations for XP_006533155.1

UniProtKB/Swiss-Prot

A2A870, A2A871, B2RQ77, Q8BSP0, Q99MZ9

Related

ENSMUSP00000099320.2, ENSMUST00000103031.8

Conserved Domains (2) summary

PHA03247
Location:69 → 530

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:602 → 1088

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_030245899.2 → XP_030101759.1 fas-binding factor 1 isoform X2

UniProtKB/TrEMBL

B7ZN01

Conserved Domains (2) summary

PHA03247
Location:69 → 529

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:601 → 1087

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_011248949.3 → XP_011247251.1 fas-binding factor 1 isoform X2

See identical proteins and their annotated locations for XP_011247251.1

UniProtKB/TrEMBL

B7ZN01

Conserved Domains (2) summary

PHA03247
Location:69 → 529

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:601 → 1087

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_030245898.2 → XP_030101758.1 fas-binding factor 1 isoform X1

UniProtKB/Swiss-Prot

A2A870, A2A871, B2RQ77, Q8BSP0, Q99MZ9

Conserved Domains (2) summary

PHA03247
Location:69 → 530

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:602 → 1088

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_036156612.1 → XP_036012505.1 fas-binding factor 1 isoform X6

Conserved Domains (2) summary

PHA03307
Location:20 → 358

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:501 → 987

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_030245900.2 → XP_030101760.1 fas-binding factor 1 isoform X4

Conserved Domains (2) summary

PHA03247
Location:65 → 525

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:597 → 1083

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_036156611.1 → XP_036012504.1 fas-binding factor 1 isoform X6

Conserved Domains (2) summary

PHA03307
Location:20 → 358

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:501 → 987

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_036156614.1 → XP_036012507.1 fas-binding factor 1 isoform X8

Conserved Domains (3) summary

PHA03247
Location:222 → 423

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:14 → 352

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:495 → 981

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_006533096.5 → XP_006533159.1 fas-binding factor 1 isoform X3

Conserved Domains (2) summary

PHA03247
Location:65 → 526

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:598 → 1084

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_036156613.1 → XP_036012506.1 fas-binding factor 1 isoform X7

Conserved Domains (3) summary

PHA03247
Location:222 → 424

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:14 → 353

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:496 → 982

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_036156609.1 → XP_036012502.1 fas-binding factor 1 isoform X5

Conserved Domains (3) summary

PHA03247
Location:228 → 430

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:20 → 359

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:502 → 988

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_036156608.1 → XP_036012501.1 fas-binding factor 1 isoform X5

Conserved Domains (3) summary

PHA03247
Location:228 → 430

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:20 → 359

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:502 → 988

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_030245901.1 → XP_030101761.1 fas-binding factor 1 isoform X5

Conserved Domains (3) summary

PHA03247
Location:228 → 430

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:20 → 359

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:502 → 988

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_036156610.1 → XP_036012503.1 fas-binding factor 1 isoform X5

Conserved Domains (3) summary

PHA03247
Location:228 → 430

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:20 → 359

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:502 → 988

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_011248950.1 → XP_011247252.1 fas-binding factor 1 isoform X5

See identical proteins and their annotated locations for XP_011247252.1

Conserved Domains (3) summary

PHA03247
Location:228 → 430

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:20 → 359

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:502 → 988

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]