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    Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha [ Mus musculus (house mouse) ]

    Gene ID: 19084, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prkar1aprovided by MGI
    Official Full Name
    protein kinase, cAMP dependent regulatory, type I, alphaprovided by MGI
    Primary source
    MGI:MGI:104878
    See related
    Ensembl:ENSMUSG00000020612 AllianceGenome:MGI:104878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tse1; Tse-1; RIalpha; 1300018C22Rik
    Summary
    The encoded protein is a regulatory subunit of the cAMP-dependent protein kinase (PKA) complex, which is responsible for transducing most of the cAMP signals in eukaryotic cells. The inactive PKA complex contains two regulatory and two catalytic subunits. Binding of cAMP dissociates the complex, allowing monomeric catalytic subunits to phosphorylate cytosolic proteins or induce gene expression in the nucleus. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 81.7), cerebellum adult (RPKM 81.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Prkar1a in Genome Data Viewer
    Location:
    11 E1; 11 72.33 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109539849..109560489)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109649023..109669663)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7089 Neighboring gene predicted gene, 39442 Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene STARR-positive B cell enhancer ABC_E259 Neighboring gene STARR-positive B cell enhancer ABC_E11498 Neighboring gene predicted gene 11685 Neighboring gene STARR-seq mESC enhancer starr_31024 Neighboring gene STARR-positive B cell enhancer ABC_E7090 Neighboring gene predicted gene, 39443 Neighboring gene STARR-positive B cell enhancer mm9_chr11:109531775-109532076 Neighboring gene STARR-positive B cell enhancer mm9_chr11:109533241-109533541 Neighboring gene FAM20A, golgi associated secretory pathway pseudokinase Neighboring gene uncharacterized LOC105243553 Neighboring gene STARR-seq mESC enhancer starr_31027 Neighboring gene STARR-seq mESC enhancer starr_31028 Neighboring gene STARR-seq mESC enhancer starr_31029 Neighboring gene predicted gene, 42093

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP binding  
    enables cAMP binding  
    enables cAMP binding  
    enables cAMP-dependent protein kinase inhibitor activity  
    enables cAMP-dependent protein kinase inhibitor activity PubMed 
    enables cAMP-dependent protein kinase inhibitor activity  
    enables cAMP-dependent protein kinase regulator activity PubMed 
    enables cAMP-dependent protein kinase regulator activity PubMed 
    enables cAMP-dependent protein kinase regulator activity PubMed 
    enables cAMP-dependent protein kinase regulator activity  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein kinase A catalytic subunit binding  
    enables protein kinase A catalytic subunit binding PubMed 
    enables protein kinase A catalytic subunit binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    acts_upstream_of_or_within cardiac muscle cell proliferation PubMed 
    involved_in cellular response to glucagon stimulus PubMed 
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within mesenchymal cell proliferation PubMed 
    acts_upstream_of_or_within mesoderm formation PubMed 
    involved_in negative regulation of activated T cell proliferation  
    involved_in negative regulation of activated T cell proliferation  
    involved_in negative regulation of cAMP/PKA signal transduction  
    involved_in negative regulation of cAMP/PKA signal transduction  
    involved_in negative regulation of gene expression  
    acts_upstream_of negative regulation of gene expression  
    acts_upstream_of_or_within negative regulation of protein kinase activity PubMed 
    involved_in positive regulation of insulin secretion PubMed 
    acts_upstream_of_or_within protein phosphorylation PubMed 
    acts_upstream_of_or_within sarcomere organization PubMed 
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    located_in axoneme  
    colocalizes_with axoneme  
    part_of cAMP-dependent protein kinase complex  
    part_of cAMP-dependent protein kinase complex PubMed 
    part_of cAMP-dependent protein kinase complex  
    located_in centrosome PubMed 
    is_active_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    is_active_in cytosol PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in immunological synapse  
    colocalizes_with immunological synapse  
    located_in multivesicular body PubMed 
    located_in neuromuscular junction PubMed 
    part_of nucleotide-activated protein kinase complex  
    part_of nucleotide-activated protein kinase complex  
    located_in plasma membrane raft  
    located_in plasma membrane raft  
    part_of protein-containing complex  
    located_in sperm head-tail coupling apparatus PubMed 
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    cAMP-dependent protein kinase type I-alpha regulatory subunit
    Names
    protein kinase, cAMP dependent regulatory, type 1, alpha
    NP_001300902.1
    NP_001300903.1
    NP_001300904.1
    NP_001300905.1
    NP_001349606.1
    NP_001360841.1
    NP_001360842.1
    NP_068680.1
    XP_036012323.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313973.2NP_001300902.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BB610165, BP754173, BY309580
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6
      UniProtKB/TrEMBL
      Q8C3Z4
      Related
      ENSMUSP00000102288.2, ENSMUST00000106677.8
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    2. NM_001313974.2NP_001300903.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BP754173, BY129491
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6
      UniProtKB/TrEMBL
      Q8C3Z4
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    3. NM_001313975.2NP_001300904.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BB850806, BP754173, CX243222
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6
      UniProtKB/TrEMBL
      Q8C3Z4
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    4. NM_001313976.2NP_001300905.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BB850806, BP754173, CF727817
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6
      UniProtKB/TrEMBL
      Q8C3Z4
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    5. NM_001362677.1NP_001349606.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AL732387, BP754173
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6
      UniProtKB/TrEMBL
      Q8C3Z4
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    6. NM_001373912.1NP_001360841.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK158562, AL732387
      UniProtKB/Swiss-Prot
      Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6
      UniProtKB/TrEMBL
      Q8C3Z4
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    7. NM_001373913.1NP_001360842.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK005039, AL732387
      UniProtKB/Swiss-Prot
      Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6
      UniProtKB/TrEMBL
      Q8C3Z4
      Related
      ENSMUSP00000056500.7, ENSMUST00000049527.7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    8. NM_021880.4NP_068680.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      See identical proteins and their annotated locations for NP_068680.1

      Status: REVIEWED

      Source sequence(s)
      AL732387, BP754173
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6
      UniProtKB/TrEMBL
      Q8C3Z4
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      109539849..109560489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156430.1XP_036012323.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

      UniProtKB/Swiss-Prot
      Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6
      UniProtKB/TrEMBL
      Q8C3Z4
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
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