U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Prpf19 pre-mRNA processing factor 19 [ Mus musculus (house mouse) ]

    Gene ID: 28000, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prpf19provided by MGI
    Official Full Name
    pre-mRNA processing factor 19provided by MGI
    Primary source
    MGI:MGI:106247
    See related
    Ensembl:ENSMUSG00000024735 AllianceGenome:MGI:106247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSO4; Snev; Prp19; NMP200; D19Wsu55e
    Summary
    Predicted to enable identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in proteasomal protein catabolic process. Acts upstream of or within lipid biosynthetic process and positive regulation of mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including extraembryonic component and genitourinary system. Orthologous to human PRPF19 (pre-mRNA processing factor 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 53.7), adrenal adult (RPKM 44.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prpf19 in Genome Data Viewer
    Location:
    19 A; 19 7.33 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10872595..10886923)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10895231..10909559)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 15, member 3 Neighboring gene transmembrane protein 132A Neighboring gene transmembrane protein 109 Neighboring gene STARR-positive B cell enhancer ABC_E2520 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10956481-10956590 Neighboring gene STARR-positive B cell enhancer ABC_E8738 Neighboring gene zona pellucida glycoprotein 1 Neighboring gene prostaglandin D2 receptor 2 Neighboring gene coiled-coil domain containing 86

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding  
    enables identical protein binding  
    enables protein binding PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-ubiquitin ligase activity  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling  
    involved_in DNA damage checkpoint signaling  
    involved_in double-strand break repair via nonhomologous end joining  
    involved_in double-strand break repair via nonhomologous end joining  
    acts_upstream_of_or_within lipid biosynthetic process PubMed 
    involved_in mRNA splicing, via spliceosome  
    involved_in mRNA splicing, via spliceosome  
    involved_in mRNA splicing, via spliceosome  
    involved_in mRNA splicing, via spliceosome PubMed 
    involved_in positive regulation of astrocyte differentiation  
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome PubMed 
    involved_in proteasomal protein catabolic process PubMed 
    involved_in proteasomal protein catabolic process  
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein localization  
    involved_in protein localization  
    acts_upstream_of_or_within protein polyubiquitination  
    involved_in spliceosomal complex assembly  
    involved_in spliceosomal complex assembly  
    involved_in spliceosomal tri-snRNP complex assembly  
    involved_in spliceosomal tri-snRNP complex assembly  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex  
    part_of DNA replication factor A complex  
    part_of Prp19 complex  
    part_of Prp19 complex  
    part_of Prp19 complex  
    part_of U2-type catalytic step 1 spliceosome  
    part_of U2-type catalytic step 2 spliceosome  
    part_of U2-type catalytic step 2 spliceosome  
    part_of catalytic step 2 spliceosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in lipid droplet  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in site of double-strand break  
    located_in site of double-strand break  
    located_in spindle  
    part_of spliceosomal complex PubMed 

    General protein information

    Preferred Names
    pre-mRNA-processing factor 19
    Names
    PRP19/PSO4 homolog
    PRP19/PSO4 pre-mRNA processing factor 19 homolog
    RING-type E3 ubiquitin transferase PRP19
    nuclear matrix protein 200
    nuclear matrix protein SNEV
    prp19 beta
    senescence evasion factor
    NP_001240772.1
    NP_001240773.1
    NP_598890.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253843.1NP_001240772.1  pre-mRNA-processing factor 19 isoform 1

      See identical proteins and their annotated locations for NP_001240772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC132402, AK047693
      Consensus CDS
      CCDS57135.1
      UniProtKB/Swiss-Prot
      Q99KP6
      Related
      ENSMUSP00000136858.3, ENSMUST00000179297.3
      Conserved Domains (4) summary
      cd00200
      Location:242522
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:243281
      7WD40; WD40 repeat [structural motif]
      cd16656
      Location:456
      RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
      pfam08606
      Location:69152
      Prp19; Prp19/Pso4-like
    2. NM_001253844.1NP_001240773.1  pre-mRNA-processing factor 19 isoform 3

      See identical proteins and their annotated locations for NP_001240773.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC132402, AK076998
      UniProtKB/Swiss-Prot
      Q99KP6
      Conserved Domains (3) summary
      cd00200
      Location:138418
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:139177
      7WD40; WD40 repeat [structural motif]
      pfam08606
      Location:148
      Prp19; Prp19/Pso4-like
    3. NM_134129.4NP_598890.1  pre-mRNA-processing factor 19 isoform 2

      See identical proteins and their annotated locations for NP_598890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC132402, AK164681
      Consensus CDS
      CCDS79687.1
      UniProtKB/Swiss-Prot
      Q3TP64, Q4ADG5, Q8BKZ5, Q8BVQ4, Q99KP6
      Related
      ENSMUSP00000025642.9, ENSMUST00000025642.14
      Conserved Domains (4) summary
      cd00200
      Location:223503
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:224262
      7WD40; WD40 repeat [structural motif]
      cd16656
      Location:456
      RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
      pfam08606
      Location:69133
      Prp19; Prp19/Pso4-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10872595..10886923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.