Mcm7 minichromosome maintenance complex component 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mcm7provided by MGI
Official Full Name: minichromosome maintenance complex component 7provided by MGI
Primary source: MGI:MGI:1298398
See related: Ensembl:ENSMUSG00000029730 AllianceGenome:MGI:1298398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mcmd7; mCDC47
Summary: Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA unwinding involved in DNA replication; cell population proliferation; and cellular response to xenobiotic stimulus. Located in nucleus. Part of MCM complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14 (RPKM 73.1), liver E14.5 (RPKM 66.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.97 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (138162845..138170675, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (138164583..138172111, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
Title: Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
cellular DNA replication factor MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by green tea catechins
Title: Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.
DNA binding and helicase activities of Mcm4/6/7 are significantly stimulated by Cdt1
Title: Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.
Accumulation and dynamics of Mcm7 are described during oogenesis and the first embryonic cell cycle.
Title: Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle.
Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
Title: DNA binding and helicase actions of mouse MCM4/6/7 helicase.
role of subunits in DNA helicases activity
Title: Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex.
cyclin D1/CDK4 complexes play a direct role in altering an inhibitory RB.MCM7 complex possibly allowing for setting of the origin in preparation for DNA replication
Title: The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding.
MCM7 may be a highly informative biomarker for cervical cancer.
Title: Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mcm7 (e-PCR), detects polymorphism
- UniSTS:546580

RH128042 (e-PCR)
- UniSTS:211350

Mcm7 (e-PCR), detects polymorphism
- UniSTS:507059

AI747533 (e-PCR)
- UniSTS:180922

Mcmd7 (e-PCR), detects polymorphism
- UniSTS:143843

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to DNA helicase activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to DNA helicase activity	ISO Inferred from Sequence Orthology more info
contributes_to DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
contributes_to single-stranded DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables single-stranded DNA binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
involved_in DNA strand elongation involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA unwinding involved in DNA replication	IPI Inferred from Physical Interaction more info	PubMed
involved_in DNA unwinding involved in DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via break-induced replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in premeiotic DNA replication	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CMG complex	ISO Inferred from Sequence Orthology more info
part_of CMG complex	ISS Inferred from Sequence or Structural Similarity more info
part_of MCM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MCM complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM complex	ISO Inferred from Sequence Orthology more info
part_of MCM complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: DNA replication licensing factor MCM7

Names: CDC47 homolog; mini chromosome maintenance deficient 7; minichromosome maintenance deficient 7

NP_001343505.1

EC 3.6.4.12

NP_001343506.1

EC 3.6.4.12

NP_032594.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356576.1 → NP_001343505.1 DNA replication licensing factor MCM7 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC151719

UniProtKB/TrEMBL

Q3V122

Conserved Domains (1) summary

smart00350
Location:38 → 534

MCM; minichromosome maintenance proteins
NM_001356577.1 → NP_001343506.1 DNA replication licensing factor MCM7 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC151719

UniProtKB/TrEMBL

Q3V122

Conserved Domains (1) summary

smart00350
Location:38 → 534

MCM; minichromosome maintenance proteins
NM_008568.3 → NP_032594.1 DNA replication licensing factor MCM7 isoform a

See identical proteins and their annotated locations for NP_032594.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC151719, AK133091

Consensus CDS

CCDS19793.1

UniProtKB/Swiss-Prot

Q61881

UniProtKB/TrEMBL

Q3U4T8, Q3UDI8, Q3V122

Related

ENSMUSP00000000505.10, ENSMUST00000000505.16

Conserved Domains (3) summary

smart00350
Location:145 → 641

MCM; minichromosome maintenance proteins

pfam14551
Location:12 → 165

MCM_N; MCM N-terminal domain

cl21455
Location:376 → 515

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases