FIG4 phosphatidylinositol-3,5-bisphosphate 5-phosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FIG4
Official Full Name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase
Primary source: SGD:S000005269
Locus tag: YNL325C
See related: AllianceGenome:SGD:S000005269; FungiDB:YNL325C; VEuPathDB:YNL325C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity. Involved in phosphatidylinositol dephosphorylation. Located in fungal-type vacuole membrane and nuclear periphery. Part of PAS complex. Used to study Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Orthologous to human FIG4 (FIG4 phosphoinositide 5-phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FIG4 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (28739..31378, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fab1 phosphoinositide kinase signaling complex assembly requires the Fig4 phosphoinositide phosphatase
Title: Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase.
This study showed that Fig4 is reguired for the rise and fall of the stress-induced phosphatidylinositol 3,5-biophosphate levels.
Title: Phosphoinositide 5-phosphatase Fig 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels.
Vac14p-Fig4p complex controls the hyperosmotic shock-induced increase in phosphatidylinositol 3,5-diphosphate levels.
Title: The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3690 (e-PCR)
- UniSTS:474268

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol bisphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol dephosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PAS complex	IDA Inferred from Direct Assay more info	PubMed
part_of PAS complex	IPI Inferred from Physical Interaction more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol-3,5-bisphosphate 5-phosphatase

NP_014074.1

Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

28739..31378 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183163.1 → NP_014074.1 TPA: phosphatidylinositol-3,5-bisphosphate 5-phosphatase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014074.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0M2, P42837

UniProtKB/TrEMBL

G2WLE6, N1NXZ9

Conserved Domains (1) summary

COG5329
Location:31 → 653

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]