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    LRP6 LDL receptor related protein 6 [ Homo sapiens (human) ]

    Gene ID: 4040, updated on 4-Jan-2025

    Summary

    Official Symbol
    LRP6provided by HGNC
    Official Full Name
    LDL receptor related protein 6provided by HGNC
    Primary source
    HGNC:HGNC:6698
    See related
    Ensembl:ENSG00000070018 MIM:603507; AllianceGenome:HGNC:6698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADCAD2; STHAG7
    Summary
    This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
    Expression
    Ubiquitous expression in placenta (RPKM 10.1), ovary (RPKM 7.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LRP6 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12116025..12267044, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (11985150..12136111, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12268959..12419978, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:12210407-12211072 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:12211073-12211736 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:12216444-12216992 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:12222531-12222710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6009 Neighboring gene BCL2 like 14 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:12225917-12226604 Neighboring gene Sharpr-MPRA regulatory region 14349 Neighboring gene Sharpr-MPRA regulatory region 8243 Neighboring gene microRNA 1244-4 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:12283961-12284161 Neighboring gene prothymosin alpha pseudogene 9 Neighboring gene ribosomal protein L21 pseudogene 100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4250 Neighboring gene Sharpr-MPRA regulatory region 15090 Neighboring gene mortality factor 4 like 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:12368521-12369020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:12381345-12381845 Neighboring gene RNA, U6 small nuclear 545, pseudogene Neighboring gene ubiquitin-conjugating enzyme E2 variant 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:12416308-12416808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4251 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:12419985-12420621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:12436705-12437246 Neighboring gene RNA, U6 small nuclear 318, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:12478241-12478741 Neighboring gene MANSC domain containing 1 Neighboring gene ribosomal protein L23a pseudogene 66

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (15 hits/1273 screens)

    Associated conditions

    Description Tests
    Coronary artery disease, autosomal dominant 2
    MedGen: C1970440 OMIM: 610947 GeneReviews: Not available
    Compare labs
    Tooth agenesis, selective, 7
    MedGen: C4225231 OMIM: 616724 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genetics of coronary artery calcification among African Americans, a meta-analysis.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ90062, FLJ90421

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Wnt signaling pathway PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
    involved_in canonical Wnt signaling pathway PubMed 
    involved_in canonical Wnt signaling pathway PubMed 
    involved_in canonical Wnt signaling pathway PubMed 
    involved_in canonical Wnt signaling pathway PubMed 
    involved_in cell-cell adhesion  
    involved_in cellular response to cholesterol PubMed 
    involved_in chemical synaptic transmission  
    involved_in dopaminergic neuron differentiation  
    involved_in endocytosis  
    involved_in midbrain dopaminergic neuron differentiation PubMed 
    involved_in negative regulation of protein serine/threonine kinase activity PubMed 
    involved_in negative regulation of smooth muscle cell apoptotic process PubMed 
    involved_in nervous system development  
    involved_in neural crest cell differentiation PubMed 
    involved_in neural crest formation PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of cell cycle PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in protein localization to plasma membrane PubMed 
    involved_in response to peptide hormone  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    colocalizes_with Golgi apparatus PubMed 
    part_of Wnt signalosome PubMed 
    part_of Wnt signalosome PubMed 
    part_of Wnt-Frizzled-LRP5/6 complex PubMed 
    part_of Wnt-Frizzled-LRP5/6 complex PubMed 
    part_of Wnt-Frizzled-LRP5/6 complex PubMed 
    colocalizes_with caveola PubMed 
    located_in cell surface PubMed 
    located_in cytoplasmic vesicle PubMed 
    colocalizes_with early endosome PubMed 
    located_in early endosome membrane  
    located_in endoplasmic reticulum  
    located_in extracellular region  
    located_in neuronal cell body  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in synapse  

    General protein information

    Preferred Names
    low-density lipoprotein receptor-related protein 6
    Names
    LRP-6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016168.2 RefSeqGene

      Range
      4834..155853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001414244.1 → NP_001401173.1  low-density lipoprotein receptor-related protein 6 isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      B7ZLD0
    2. NM_001414245.1 → NP_001401174.1  low-density lipoprotein receptor-related protein 6 isoform b precursor

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/Swiss-Prot
      O75581, Q17RZ2
      UniProtKB/TrEMBL
      B7ZLD0
    3. NM_001414246.1 → NP_001401175.1  low-density lipoprotein receptor-related protein 6 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      B7ZLD0, F5H7J9
      Related
      ENSP00000442472.1, ENST00000543091.1
    4. NM_001414247.1 → NP_001401176.1  low-density lipoprotein receptor-related protein 6 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      B7ZLD0
    5. NM_001414248.1 → NP_001401177.1  low-density lipoprotein receptor-related protein 6 isoform e precursor

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      B7ZLD0
    6. NM_001414249.1 → NP_001401178.1  low-density lipoprotein receptor-related protein 6 isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      B7ZLD0
    7. NM_001414250.1 → NP_001401179.1  low-density lipoprotein receptor-related protein 6 isoform g precursor

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      B7ZLD0
    8. NM_001414251.1 → NP_001401180.1  low-density lipoprotein receptor-related protein 6 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      B7ZLD0
    9. NM_001414252.1 → NP_001401181.1  low-density lipoprotein receptor-related protein 6 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      H0YGW5, Q59EX8
    10. NM_001414253.1 → NP_001401182.1  low-density lipoprotein receptor-related protein 6 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      H0YGW5, Q59EX8
    11. NM_001414254.1 → NP_001401183.1  low-density lipoprotein receptor-related protein 6 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      H0YGW5, Q59EX8
    12. NM_001414255.1 → NP_001401184.1  low-density lipoprotein receptor-related protein 6 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603
      UniProtKB/TrEMBL
      B7ZLD0
    13. NM_002336.3 → NP_002327.2  low-density lipoprotein receptor-related protein 6 isoform b precursor

      See identical proteins and their annotated locations for NP_002327.2

      Status: REVIEWED

      Source sequence(s)
      AA126261, AC007537, AC007621, AF074264, BC126405, BP229563
      Consensus CDS
      CCDS8647.1
      UniProtKB/Swiss-Prot
      O75581, Q17RZ2
      UniProtKB/TrEMBL
      B7ZLD0
      Related
      ENSP00000261349.4, ENST00000261349.9
      Conserved Domains (6) summary
      smart00135
      Location:483 → 524
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:1326 → 1360
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:55 → 93
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:150 → 190
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:592 → 627
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:55 → 272
      NHL; NHL repeat unit of beta-propeller proteins

    RNA

    1. NR_182264.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007537, AC007621, KF455603

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      12116025..12267044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428844.1 → XP_047284800.1  low-density lipoprotein receptor-related protein 6 isoform X1

      UniProtKB/TrEMBL
      H0YGW5

    RNA

    1. XR_002957325.2 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_011332696.1 Reference GRCh38.p14 PATCHES

      Range
      85023..236042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331699.1 → XP_054187674.1  low-density lipoprotein receptor-related protein 6 isoform X1

      UniProtKB/TrEMBL
      H0YGW5

    RNA

    1. XR_008485729.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      11985150..12136111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372051.1 → XP_054228026.1  low-density lipoprotein receptor-related protein 6 isoform X1

      UniProtKB/TrEMBL
      Q59EX8

    RNA

    1. XR_008488585.1 RNA Sequence

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