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    PIGR polymeric immunoglobulin receptor [ Homo sapiens (human) ]

    Gene ID: 5284, updated on 9-Dec-2024

    Summary

    Official Symbol
    PIGRprovided by HGNC
    Official Full Name
    polymeric immunoglobulin receptorprovided by HGNC
    Primary source
    HGNC:HGNC:8968
    See related
    Ensembl:ENSG00000162896 MIM:173880; AllianceGenome:HGNC:8968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
    Expression
    Biased expression in duodenum (RPKM 1246.3), colon (RPKM 1042.2) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PIGR in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206928522..206946466, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206193722..206211683, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207101867..207119811, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2426 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:207078063-207079262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1768 Neighboring gene interleukin 24 Neighboring gene negCOR silencer S10 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene Fc mu receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:207103683-207104183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1769 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207134913-207136112 Neighboring gene Fc alpha and mu receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2438 Neighboring gene tRNA-Pro (anticodon TGG) 5-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22667, MGC125361, MGC125362

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables polymeric immunoglobulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polymeric immunoglobulin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    polymeric immunoglobulin receptor
    Names
    hepatocellular carcinoma associated protein TB6
    poly-Ig receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012927.1 RefSeqGene

      Range
      5001..22945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002644.4NP_002635.2  polymeric immunoglobulin receptor precursor

      See identical proteins and their annotated locations for NP_002635.2

      Status: REVIEWED

      Source sequence(s)
      AF272149, AK225471
      Consensus CDS
      CCDS1474.1
      UniProtKB/Swiss-Prot
      P01833, Q68D81, Q8IZY7
      Related
      ENSP00000348888.4, ENST00000356495.5
      Conserved Domains (1) summary
      cd05716
      Location:464560
      IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      206928522..206946466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509629.2XP_011507931.1  polymeric immunoglobulin receptor isoform X1

      See identical proteins and their annotated locations for XP_011507931.1

      UniProtKB/Swiss-Prot
      P01833, Q68D81, Q8IZY7
      Conserved Domains (1) summary
      cd05716
      Location:464560
      IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      206193722..206211683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337031.1XP_054193006.1  polymeric immunoglobulin receptor isoform X1

      UniProtKB/Swiss-Prot
      P01833, Q68D81, Q8IZY7