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    TMF1 TATA element modulatory factor 1 [ Homo sapiens (human) ]

    Gene ID: 7110, updated on 10-Dec-2024

    Summary

    Official Symbol
    TMF1provided by HGNC
    Official Full Name
    TATA element modulatory factor 1provided by HGNC
    Primary source
    HGNC:HGNC:11870
    See related
    Ensembl:ENSG00000144747 MIM:601126; AllianceGenome:HGNC:11870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMF; ARA160
    Summary
    Enables nuclear androgen receptor binding activity and nuclear receptor coactivator activity. Involved in androgen receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 20.2), thyroid (RPKM 13.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TMF1 in Genome Data Viewer
    Location:
    3p14.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (69019827..69052333, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (69056599..69089119, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (69068978..69101484, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 4 Neighboring gene RNA, 5S ribosomal pseudogene 135 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:68968097-68968699 Neighboring gene Sharpr-MPRA regulatory region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14515 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene EOGT divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20050 Neighboring gene microRNA 3136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20053 Neighboring gene ubiquitin like modifier activating enzyme 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:69152971-69154170 Neighboring gene ARF like GTPase 6 interacting protein 5 Neighboring gene leiomodin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding  
    enables nuclear androgen receptor binding PubMed 
    enables nuclear receptor coactivator activity PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in cytosol  
    is_active_in endoplasmic reticulum  
    located_in nucleus  

    General protein information

    Preferred Names
    TATA element modulatory factor
    Names
    androgen receptor coactivator 160 kDa protein
    androgen receptor-associated protein of 160 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363879.1 → NP_001350808.1  TATA element modulatory factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109587, BC143840, DC401240
      Consensus CDS
      CCDS87105.1
      UniProtKB/TrEMBL
      B4DQY7
      Related
      ENSP00000494067.1, ENST00000646708.1
      Conserved Domains (2) summary
      pfam12325
      Location:979 → 1090
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
      cl25732
      Location:457 → 1093
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_007114.3 → NP_009045.2  TATA element modulatory factor isoform 1

      See identical proteins and their annotated locations for NP_009045.2

      Status: VALIDATED

      Source sequence(s)
      AB209109, AC109587, AL040699, BC033771, BU689613
      Consensus CDS
      CCDS43105.1
      UniProtKB/Swiss-Prot
      B7ZLJ2, P82094, Q17R87, Q59GK0
      UniProtKB/TrEMBL
      B4DQY7
      Related
      ENSP00000381567.2, ENST00000398559.7
      Conserved Domains (5) summary
      COG4942
      Location:698 → 939
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      pfam00261
      Location:553 → 802
      Tropomyosin; Tropomyosin
      pfam12325
      Location:976 → 1087
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
      pfam12329
      Location:542 → 615
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
      cl21478
      Location:646 → 752
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      69019827..69052333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      69056599..69089119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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