SULT1A4 sulfotransferase family 1A member 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SULT1A4provided by HGNC
Official Full Name: sulfotransferase family 1A member 4provided by HGNC
Primary source: HGNC:HGNC:30004
See related: Ensembl:ENSG00000213648 MIM:615819; AllianceGenome:HGNC:30004
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STM; HAST3; M-PST; ST1A3; ST1A4; TL-PST; ST1A3/ST1A4
Summary: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
Expression: Broad expression in duodenum (RPKM 135.4), small intestine (RPKM 94.3) and 23 other tissues See more
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Genomic context

Location:: 16p11.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (29459913..29464966)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (29741703..29746756)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (29471234..29476287)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results obtained showed clearly the differential enzymatic characteristics of SULT1A3 allozymes in mediating the sulfation of phenylephrine and salbutamol. This information may contribute toward a better understanding of the pharmacokinetics of these two drugs in individuals with distinct SULT1A3 and/or SULT1A4 genotypes.
Title: Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes.
Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3
Title: Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103211 (e-PCR)
- UniSTS:97544

GDB:594646 (e-PCR)
- UniSTS:158001

GDB:435498 (e-PCR)
- UniSTS:157234

RH133600 (e-PCR)
- UniSTS:216883

RH92261 (e-PCR)
- UniSTS:90951

GDB:574035 (e-PCR)
- UniSTS:157787

GDB:579633 (e-PCR)
- UniSTS:157822

RH80591 (e-PCR)
- UniSTS:84371

GDB:626005 (e-PCR)
- UniSTS:158379

GDB:626032 (e-PCR)
- UniSTS:158380

D16S3176 (e-PCR)
- UniSTS:149699

RH69023 (e-PCR)
- UniSTS:89560

GDB:453889 (e-PCR)
- UniSTS:157416

Readthrough SLX1B-SULT1A4

Readthrough gene: SLX1B-SULT1A4, Included gene: SLX1B

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables amine sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables aryl sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aryl sulfotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sulfate binding	IDA Inferred from Direct Assay more info	PubMed
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in catecholamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to dopamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ethanol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in flavonoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfation	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: sulfotransferase 1A4

Names: SLX1B-SULT1A4; Sulfotransferase 1A3; aryl sulfotransferase 1A3/1A4; catecholamine-sulfating phenol sulfotransferase; monoamine-sulfating phenol sulfotransferase; placental estrogen sulfotransferase; sulfokinase; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4; sulfotransferase, monoamine-preferring; thermolabile phenol sulfotransferase

NP_001017390.1

EC 2.8.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017390.3 → NP_001017390.1 sulfotransferase 1A4

See identical proteins and their annotated locations for NP_001017390.1

Status: REVIEWED

Source sequence(s)

AC133555

Consensus CDS

CCDS32427.1

UniProtKB/Swiss-Prot

B4DNV0, O95603, P0DMM9, P0DMN0, P50224, Q1ET66, Q6ZWJ5

UniProtKB/TrEMBL

B3KT14, Q1ET61, Q1ET62, Q1ET63, Q2TAB3

Related

ENSP00000353600.8, ENST00000360423.12

Conserved Domains (1) summary

pfam00685
Location:38 → 287

Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

29459913..29464966

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

29741703..29746756

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001017389.1: Suppressed sequence

Description

NM_001017389.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_001017391.1: Suppressed sequence

Description

NM_001017391.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.