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    ANKRD10 ankyrin repeat domain 10 [ Homo sapiens (human) ]

    Gene ID: 55608, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ANKRD10provided by HGNC
    Official Full Name
    ankyrin repeat domain 10provided by HGNC
    Primary source
    HGNC:HGNC:20265
    See related
    Ensembl:ENSG00000088448 AllianceGenome:HGNC:20265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 23.7), endometrium (RPKM 23.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ANKRD10 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (110878540..110915069, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (110108631..110144952, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111530887..111567416, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111502835-111503338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111503339-111503840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111505979-111506517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5519 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:111521756-111522955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111525201-111526078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5520 Neighboring gene p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111558775-111559276 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:111560595-111561212 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111566028-111566704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5522 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111568056-111568730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111581847-111582346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8019 Neighboring gene uncharacterized LOC105370364 Neighboring gene poly(ADP-ribose) polymerase 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111608267-111609068 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:111609334-111610533 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:111617326-111618525 Neighboring gene long intergenic non-protein coding RNA 431

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20093, DKFZp686B07190

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chloroplast targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting to chloroplast IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286721.3 → NP_001273650.1  ankyrin repeat domain-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001273650.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and contains multiple differences in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL442128
      Consensus CDS
      CCDS66580.1
      UniProtKB/Swiss-Prot
      Q9NXR5
      Related
      ENSP00000312534.4, ENST00000310847.8
      Conserved Domains (3) summary
      sd00045
      Location:57 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:25 → 74
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:63 → 151
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_017664.4 → NP_060134.2  ankyrin repeat domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_060134.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK000100, AK094222, AL157875
      Consensus CDS
      CCDS9520.1
      UniProtKB/Swiss-Prot
      Q5VW12, Q9BV12, Q9NXR5
      Related
      ENSP00000267339.2, ENST00000267339.6
      Conserved Domains (5) summary
      COG0666
      Location:111 → 217
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:57 → 178
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:63 → 155
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:25 → 78
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:57 → 89
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_104586.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL442128

    2. NR_104587.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL157875, BX354283, DA961131

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      110878540..110915069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449380.2 → XP_024305148.1  ankyrin repeat domain-containing protein 10 isoform X1

      Conserved Domains (3) summary
      cd00204
      Location:57 → 178
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:57 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:25 → 74
      Ank_4; Ankyrin repeats (many copies)

    2. XM_024449382.2 → XP_024305150.1  ankyrin repeat domain-containing protein 10 isoform X3

      Conserved Domains (2) summary
      cd00204
      Location:25 → 145
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:57 → 89
      ANK; ANK repeat [structural motif]

    3. XM_024449381.2 → XP_024305149.1  ankyrin repeat domain-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      Q8IUW1
      Related
      ENSP00000431927.1, ENST00000465753.1
      Conserved Domains (2) summary
      cd00204
      Location:25 → 145
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:57 → 89
      ANK; ANK repeat [structural motif]

    4. XM_024449383.2 → XP_024305151.1  ankyrin repeat domain-containing protein 10 isoform X4

      Conserved Domains (2) summary
      cd00204
      Location:25 → 145
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:57 → 89
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_007063690.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      110108631..110144952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374725.1 → XP_054230700.1  ankyrin repeat domain-containing protein 10 isoform X1

    2. XM_054374727.1 → XP_054230702.1  ankyrin repeat domain-containing protein 10 isoform X3

    3. XM_054374726.1 → XP_054230701.1  ankyrin repeat domain-containing protein 10 isoform X2

    4. XM_054374728.1 → XP_054230703.1  ankyrin repeat domain-containing protein 10 isoform X4

    RNA

    1. XR_008488773.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NXR5.2 GenPept UniProtKB/Swiss-Prot:Q9NXR5

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