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    MYBL1 MYB proto-oncogene like 1 [ Homo sapiens (human) ]

    Gene ID: 4603, updated on 9-Dec-2024

    Summary

    Official Symbol
    MYBL1provided by HGNC
    Official Full Name
    MYB proto-oncogene like 1provided by HGNC
    Primary source
    HGNC:HGNC:7547
    See related
    Ensembl:ENSG00000185697 MIM:159405; AllianceGenome:HGNC:7547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMYB; A-MYB
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lymph node (RPKM 9.0), testis (RPKM 6.1) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MYBL1 in Genome Data Viewer
    Location:
    8q13.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (66562175..66613218, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (66987925..67038972, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67474410..67525453, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1324, pseudogene Neighboring gene uncharacterized LOC124901955 Neighboring gene vexin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:67453792-67454308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27482 Neighboring gene MPRA-validated peak7058 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:67504290-67504448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19254 Neighboring gene uncharacterized LOC105375884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27485 Neighboring gene valosin containing protein interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27490

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC120059, MGC120061

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male meiosis I ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of piRNA transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    myb-related protein A
    Names
    myb-like protein 1
    v-myb avian myeloblastosis viral oncogene homolog-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080416.4NP_001073885.1  myb-related protein A isoform 1

      See identical proteins and their annotated locations for NP_001073885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC083928, DR003430, X13294
      Consensus CDS
      CCDS47867.1
      UniProtKB/Swiss-Prot
      E7EW29, P10243, Q495F9
      Related
      ENSP00000429633.2, ENST00000522677.8
      Conserved Domains (4) summary
      smart00717
      Location:87135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242286
      LMSTEN; LMSTEN motif
      pfam09316
      Location:486647
      Cmyb_C; C-myb, C-terminal
    2. NM_001144755.3NP_001138227.1  myb-related protein A isoform 2

      See identical proteins and their annotated locations for NP_001138227.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC083928, BC101188, DR003430
      Consensus CDS
      CCDS55241.1
      UniProtKB/Swiss-Prot
      P10243
      Related
      ENSP00000428011.2, ENST00000524176.2
      Conserved Domains (3) summary
      pfam09316
      Location:486647
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:3898
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:84270
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    3. NM_001294282.2NP_001281211.1  myb-related protein A isoform 3

      See identical proteins and their annotated locations for NP_001281211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC083928, BC101186, DR003430
      UniProtKB/TrEMBL
      Q495G0
      Conserved Domains (3) summary
      pfam09316
      Location:485646
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:3898
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:84270
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      66562175..66613218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517535.4XP_011515837.1  myb-related protein A isoform X6

      Conserved Domains (4) summary
      smart00717
      Location:87135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242286
      LMSTEN; LMSTEN motif
      pfam09316
      Location:491652
      Cmyb_C; C-myb, C-terminal
    2. XM_011517533.4XP_011515835.1  myb-related protein A isoform X3

      Conserved Domains (4) summary
      smart00717
      Location:87135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242286
      LMSTEN; LMSTEN motif
      pfam09316
      Location:491652
      Cmyb_C; C-myb, C-terminal
    3. XM_017013455.2XP_016868944.1  myb-related protein A isoform X1

    4. XM_017013456.2XP_016868945.1  myb-related protein A isoform X2

    5. XM_017013457.2XP_016868946.1  myb-related protein A isoform X4

    6. XM_017013458.2XP_016868947.1  myb-related protein A isoform X5

    7. XM_017013459.2XP_016868948.1  myb-related protein A isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      66987925..67038972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360506.1XP_054216481.1  myb-related protein A isoform X6

    2. XM_054360503.1XP_054216478.1  myb-related protein A isoform X3

    3. XM_054360501.1XP_054216476.1  myb-related protein A isoform X1

    4. XM_054360502.1XP_054216477.1  myb-related protein A isoform X2

    5. XM_054360504.1XP_054216479.1  myb-related protein A isoform X4

    6. XM_054360505.1XP_054216480.1  myb-related protein A isoform X5

    7. XM_054360507.1XP_054216482.1  myb-related protein A isoform X7