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    PMP2 proteolipid ATPase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856697, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PMP2
    Official Full Name
    proteolipid ATPase
    Primary source
    SGD:S000002103
    Locus tag
    YEL017C-A
    See related
    AllianceGenome:SGD:S000002103; FungiDB:YEL017C-A; VEuPathDB:YEL017C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme regulator activity. Involved in positive regulation of ATP-dependent activity. Located in membrane. Is active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PMP2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (122798..122929, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene SUMO ligase MMS21 Neighboring gene Eaf5p Neighboring gene Gtt3p Neighboring gene nucleotide diphosphatase/phosphodiesterase NPP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plasma membrane H(+)-ATPase of Saccharomyces cerevisiae is regulated by two small 38-residue isoproteolipids. Navarre C, et al. Folia Microbiol (Praha), 1998. PMID 9721615
    2. Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae. Navarre C, et al. J Biol Chem, 1994 Aug 19. PMID 8063750
    3. A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast. Michelsen K, et al. Traffic, 2006 Jul. PMID 16734667
    4. Divergent RNA binding specificity of yeast Puf2p. Yosefzon Y, et al. RNA, 2011 Aug. PMID 21685478, Free PMC Article
    5. Global identification of new substrates for the yeast endoribonuclease, RNase mitochondrial RNA processing (MRP). Aulds J, et al. J Biol Chem, 2012 Oct 26. PMID 22977255, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. role of 14-3-3 in the trafficking of this multimeric Pmp2p reporter is isoform-specific
      Title: A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of ATP-dependent activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteolipid ATPase
    NP_010898.1
    • Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      122798..122929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180029.1 → NP_010898.1  TPA: proteolipid ATPase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010898.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLN2, P40975
      UniProtKB/TrEMBL
      A6ZQT2, B3LRZ9, C7GX26, C8Z6Y2, G2WCL5, N1P5M1
      Conserved Domains (1) summary
      pfam08114
      Location:1 → 43
      PMP1_2; ATPase proteolipid family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40975.1

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