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    HSPA9 heat shock protein family A (Hsp70) member 9 [ Homo sapiens (human) ]

    Gene ID: 3313, updated on 27-Nov-2024

    Summary

    Official Symbol
    HSPA9provided by HGNC
    Official Full Name
    heat shock protein family A (Hsp70) member 9provided by HGNC
    Primary source
    HGNC:HGNC:5244
    See related
    Ensembl:ENSG00000113013 MIM:600548; AllianceGenome:HGNC:5244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSA; MOT; MOT2; SAAN; CRP40; EVPLS; GRP75; PBP74; GRP-75; HSPA9B; SIDBA4; MTHSP75; HEL-S-124m
    Summary
    This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in adrenal (RPKM 109.2), thyroid (RPKM 92.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HSPA9 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (138553756..138575401, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139080003..139101647, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137889445..137911090, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137827382-137828074 Neighboring gene uncharacterized LOC124901078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137828769-137829460 Neighboring gene eukaryotic translation termination factor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137859313-137860250 Neighboring gene Sharpr-MPRA regulatory region 2814 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:137878436-137879635 Neighboring gene small nucleolar RNA, C/D box 63B Neighboring gene small nucleolar RNA, C/D box 63 Neighboring gene uncharacterized LOC105379193 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137910671-137911318 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137911319-137911967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137945276-137945908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137945909-137946541 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137946542-137947174 Neighboring gene ribosomal protein L10a pseudogene 10 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Autosomal dominant sideroblastic anemia
    MedGen: C4225428 OMIM: 182170 GeneReviews: Not available
    not available
    Even-plus syndrome
    MedGen: C4225180 OMIM: 616854 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 9B (HSPA9B), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
    env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 9B (HSPA9B), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Mortalin binds HIV-1 Nef via the Nef secretion modification region (amino acids 66 to 70), which is required for exosomal Nef secretion PubMed
    nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein heat shock 70kDa protein 9 (HSPA9) in cells PubMed
    nef Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 9B (HSPA9B), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    nef Heat shock proteins Hsp40 and Hsp70 interact with HIV-1 Nef and form a complex in cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 9B (HSPA9B), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed
    gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
    Vpr vpr HIV-1 Vpr is required for the inhibitory effect of Hsp70 on viral gene expression and replication PubMed
    vpr HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha PubMed
    matrix gag Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4500

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inner mitochondrial membrane organization IC
    Inferred by Curator
    more info
    PubMed 
    involved_in intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hematopoietic stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    stress-70 protein, mitochondrial
    Names
    75 kDa glucose-regulated protein
    catecholamine-regulated protein 40
    epididymis secretory sperm binding protein Li 124m
    heat shock 70kD protein 9B
    heat shock 70kDa protein 9 (mortalin)
    heat shock protein family A member 9
    mortalin, perinuclear
    mortalin-2
    mortalin2
    p66-mortalin
    peptide-binding protein 74

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029469.1 RefSeqGene

      Range
      5229..26874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1344

    mRNA and Protein(s)

    1. NM_004134.7NP_004125.3  stress-70 protein, mitochondrial precursor

      See identical proteins and their annotated locations for NP_004125.3

      Status: REVIEWED

      Source sequence(s)
      AC011385, AK225488, AK315177
      Consensus CDS
      CCDS4208.1
      UniProtKB/Swiss-Prot
      B2RCM1, P30036, P31932, P38646, Q1HB43, Q53H23, Q6GU03, Q9BWB7, Q9UC56
      UniProtKB/TrEMBL
      A0A384P5G6, V9HW84
      Related
      ENSP00000297185.3, ENST00000297185.9
      Conserved Domains (1) summary
      PRK00290
      Location:52673
      dnaK; molecular chaperone DnaK; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      138553756..138575401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      139080003..139101647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)