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    DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [ Homo sapiens (human) ]

    Gene ID: 22894, updated on 10-Dec-2024

    Summary

    Official Symbol
    DIS3provided by HGNC
    Official Full Name
    DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by HGNC
    Primary source
    HGNC:HGNC:20604
    See related
    Ensembl:ENSG00000083520 MIM:607533; AllianceGenome:HGNC:20604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik
    Summary
    Enables 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process; RNA processing; and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 10.1), lymph node (RPKM 7.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DIS3 in Genome Data Viewer
    Location:
    13q21.33
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (72752169..72781900, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (71973643..72003383, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (73326307..73356038, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 80, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73301228-73301409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7814 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene BORA aurora kinase A activator Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:73355230-73356144 Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73426017-73426548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:73426549-73427078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7816 Neighboring gene RNA, U6 small nuclear 79, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73509249-73509443 Neighboring gene NANOG hESC enhancer GRCh37_chr13:73534622-73535123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73610339-73611015 Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ10484, MGC33035, DKFZp667L1817

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity  
    enables 3'-5'-RNA exonuclease activity PubMed 
    enables 3'-5'-RNA exonuclease activity  
    enables RNA binding  
    enables endonuclease activity  
    enables endonuclease activity PubMed 
    enables guanyl-nucleotide exchange factor activity PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of cytoplasmic exosome (RNase complex)  
    located_in cytosol PubMed 
    located_in cytosol  
    part_of exosome (RNase complex) PubMed 
    part_of exosome (RNase complex) PubMed 
    located_in membrane PubMed 
    part_of nuclear exosome (RNase complex)  
    part_of nuclear exosome (RNase complex) PubMed 
    part_of nuclear exosome (RNase complex) PubMed 
    NOT located_in nucleolus PubMed 
    located_in nucleoplasm PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    exosome complex exonuclease RRP44
    Names
    DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
    DIS3 mitotic control homolog
    exosome component 11
    mitotic control protein dis3 homolog
    ribosomal RNA-processing protein 44

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128226.3 → NP_001121698.1  exosome complex exonuclease RRP44 isoform b

      See identical proteins and their annotated locations for NP_001121698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AB023225, AL080158, AL138695, AL832266, U79246
      Consensus CDS
      CCDS45057.1
      UniProtKB/TrEMBL
      A8QI98
      Related
      ENSP00000367011.4, ENST00000377780.8
      Conserved Domains (3) summary
      COG0557
      Location:192 → 900
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:437 → 765
      RNB; RNB domain
      cl14812
      Location:9 → 167
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    2. NM_001322348.2 → NP_001309277.1  exosome complex exonuclease RRP44 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL138695, AL391384
      UniProtKB/TrEMBL
      Q49AG4
      Conserved Domains (3) summary
      COG0557
      Location:99 → 807
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:344 → 672
      RNB; RNB domain
      cl14812
      Location:6 → 74
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    3. NM_001322349.2 → NP_001309278.1  exosome complex exonuclease RRP44 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL138695, AL391384
      Consensus CDS
      CCDS81772.1
      UniProtKB/TrEMBL
      G3V1J5, Q49AG4
      Related
      ENSP00000440058.1, ENST00000545453.5
      Conserved Domains (3) summary
      COG0557
      Location:60 → 768
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:305 → 633
      RNB; RNB domain
      cl14812
      Location:3 → 35
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    4. NM_014953.5 → NP_055768.3  exosome complex exonuclease RRP44 isoform a

      See identical proteins and their annotated locations for NP_055768.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL080158, AL138695, AL832266, BC056143, U79246
      Consensus CDS
      CCDS9447.1
      UniProtKB/Swiss-Prot
      A6NI21, B2RBL2, Q5W0P7, Q5W0P8, Q658Z7, Q7Z481, Q8WWI2, Q9UG36, Q9Y2L1
      UniProtKB/TrEMBL
      A8QI98
      Related
      ENSP00000366997.4, ENST00000377767.9
      Conserved Domains (3) summary
      cd09862
      Location:9 → 197
      PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
      COG0557
      Location:222 → 930
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:467 → 795
      RNB; RNB domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      72752169..72781900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      71973643..72003383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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