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    Pdcd2 programmed cell death 2 [ Mus musculus (house mouse) ]

    Gene ID: 18567, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdcd2provided by MGI
    Official Full Name
    programmed cell death 2provided by MGI
    Primary source
    MGI:MGI:104643
    See related
    Ensembl:ENSMUSG00000014771 AllianceGenome:MGI:104643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcd2; RP-8
    Summary
    Predicted to enable enzyme binding activity. Predicted to be involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of hematopoietic stem cell proliferation; and regulation of hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in cranial ganglion; cranial nerve; and dorsal root ganglion. Orthologous to human PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 26.0), adrenal adult (RPKM 24.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pdcd2 in Genome Data Viewer
    Location:
    17 A2; 17 8.95 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15739472..15747560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (15521575..15527319, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 1 Neighboring gene STARR-positive B cell enhancer ABC_E5573 Neighboring gene TATA box binding protein Neighboring gene STARR-positive B cell enhancer ABC_E5574 Neighboring gene zinc finger protein 91 pseudogene Neighboring gene PR domain containing 9 Neighboring gene BRCA1 associated RING domain 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of mouse RP-8 cDNA and its expression during apoptosis of lymphoid and myeloid cells. Vaux DL, et al. DNA Cell Biol, 1995 Mar. PMID 7880439
    2. PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance. Mu W, et al. Dev Biol, 2010 Nov 15. PMID 20813103, Free PMC Article
    3. Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest. Granier CJ, et al. Biol Open, 2014 Aug 22. PMID 25150276, Free PMC Article
    4. Conserved alternative and antisense transcripts at the programmed cell death 2 locus. Mihola O, et al. BMC Genomics, 2007 Jan 18. PMID 17233890, Free PMC Article
    5. Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas. Baron BW, et al. Proc Natl Acad Sci U S A, 2007 May 1. PMID 17468402, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pdcd2(-/-) embryos underwent implantation but did not undergo further development. Inner cell masses from Pdcd2(-/-) blastocysts failed to outgrow in vitro.
      Title: PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance.
    2. repression of PDCD2 by BCL6 is likely important in the pathogenesis of certain human lymphomas
      Title: Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    programmed cell death protein 2
    Names
    zinc finger protein Rp-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412856.1 → NP_001399785.1  programmed cell death protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154378

    2. NM_001412857.1 → NP_001399786.1  programmed cell death protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154378
      UniProtKB/Swiss-Prot
      P46718, Q8BR06

    3. NM_001412858.1 → NP_001399787.1  programmed cell death protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154378
      UniProtKB/TrEMBL
      Q6RI66

    4. NM_001412859.1 → NP_001399788.1  programmed cell death protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154378
      UniProtKB/Swiss-Prot
      P46718, Q8BR06

    5. NM_001412860.1 → NP_001399789.1  programmed cell death protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154378
      UniProtKB/TrEMBL
      Q6RI66

    6. NM_001412861.1 → NP_001399790.1  programmed cell death protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC154378
      UniProtKB/TrEMBL
      A2T4N6
      Related
      ENSMUSP00000118625.2, ENSMUST00000154293.8

    7. NM_001412862.1 → NP_001399791.1  programmed cell death protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC154378
      UniProtKB/Swiss-Prot
      P46718, Q8BR06

    8. NM_008799.3 → NP_032825.2  programmed cell death protein 2 isoform 1

      See identical proteins and their annotated locations for NP_032825.2

      Status: VALIDATED

      Source sequence(s)
      AC154378
      Consensus CDS
      CCDS28413.1
      UniProtKB/Swiss-Prot
      P46718, Q8BR06
      UniProtKB/TrEMBL
      A0A0R4J0N5
      Related
      ENSMUSP00000052523.7, ENSMUST00000054450.7
      Conserved Domains (2) summary
      pfam01753
      Location:134 → 171
      zf-MYND; MYND finger
      pfam04194
      Location:225 → 338
      PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

    RNA

    1. NR_182059.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154378

    2. NR_182060.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154378

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      15739472..15747560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46718.2 GenPept UniProtKB/Swiss-Prot:P46718

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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