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    Tsp42Ee Tetraspanin 42Ee [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35614, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp42Eeprovided by FlyBase
    Official Full Name
    Tetraspanin 42Eeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029506
    Locus tag
    Dmel_CG10106
    See related
    AllianceGenome:FB:FBgn0029506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.151; BcDNA:LD16071; CG10106; Dm.Tsp42Ee; Dmel\CG10106
    Summary
    Located in fusome. Is expressed in several structures, including CNS glial cell; adult head; epithelium; ganglia; and gut section. Orthologous to human TSPAN3 (tetraspanin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp42Ee in Genome Data Viewer
    Location:
    42E5-42E5; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7012254..7018362)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2899759..2905867)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42Ec Neighboring gene Tetraspanin 42Ed Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Immunoglobulin Superfamily Member Basigin Is Required for Complex Dendrite Formation in Drosophila. Shrestha BR, et al. Front Cell Neurosci, 2021. PMID 34803611, Free PMC Article
    2. The CD63 homologs, Tsp42Ee and Tsp42Eg, restrict endocytosis and promote neurotransmission through differential regulation of synaptic vesicle pools. Hendricks EL, et al. Front Cell Neurosci, 2022. PMID 36072568, Free PMC Article
    3. Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model. Linnemannstöns K, et al. J Extracell Vesicles, 2022 Sep. PMID 36103151, Free PMC Article
    4. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
    5. Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes. Beckett K, et al. Traffic, 2013 Jan. PMID 23035643, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 42Ee
    Names
    CG10106-PA
    CG10106-PB
    Tsp42Ee-PA
    Tsp42Ee-PB
    tetraspanin
    tetraspanin 42E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7012254..7018362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078907.3 → NP_523631.1  tetraspanin 42Ee, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523631.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJ73, Q8SY17
      Related
      FBpp0085512
      Conserved Domains (2) summary
      cd03127
      Location:106 → 187
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 219
      Tetraspannin; Tetraspanin family

    2. NM_001273824.1 → NP_001260753.1  tetraspanin 42Ee, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJ73, Q8SY17
      Conserved Domains (2) summary
      cd03127
      Location:106 → 187
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 219
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KJ73 Q7KJ73
    Q8SY17 Q8SY17

    Gene LinkOut

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