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    MED4 Med4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854345, updated on 9-Dec-2024

    Summary

    Official Symbol
    MED4
    Official Full Name
    Med4p
    Primary source
    SGD:S000005700
    Locus tag
    YOR174W
    See related
    AllianceGenome:SGD:S000005700; FungiDB:YOR174W; VEuPathDB:YOR174W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II core promoter sequence-specific DNA binding activity. Involved in cellular response to heat and transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See MED4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (658747..659601)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Yrm1p Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase Neighboring gene lysophospholipid acyltransferase Neighboring gene ferrochelatase HEM15

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Med4p
    NP_014817.3
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      658747..659601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183593.3NP_014817.3  TPA: Med4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014817.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2N0, Q12343
      UniProtKB/TrEMBL
      A6ZP17, B3LJK4, B5VS58, C7GN53, C8ZGT5, G2WN46, N1NVU0
      Conserved Domains (1) summary
      pfam10018
      Location:67208
      Med4; Vitamin-D-receptor interacting Mediator subunit 4