U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hasp Hig-anchoring scaffold protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35238, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Haspprovided by FlyBase
    Official Full Name
    Hig-anchoring scaffold proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032797
    Locus tag
    Dmel_CG10186
    See related
    AllianceGenome:FB:FBgn0032797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey189; CG10186; CT28647; Dmel\CG10186; hasp
    Summary
    Predicted to enable peptidase inhibitor activity. Predicted to be involved in regulation of dendrite development. Located in synaptic cleft. Is expressed in adult brain; adult head; gnathal ganglion; and mushroom body calyx. Human ortholog(s) of this gene implicated in malaria. Orthologous to human CR1 (complement C3b/C4b receptor 1 (Knops blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Hasp in Genome Data Viewer
    Location:
    37E5-37E5; 2-54 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19508953..19517204, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19508953..19517204, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Topoisomerase 3alpha Neighboring gene cysts Neighboring gene long non-coding RNA:CR43363 Neighboring gene uncharacterized protein Neighboring gene Dolichyl-phosphate mannosyltransferase subunit 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Matrix Proteins Hasp and Hig Exhibit Segregated Distribution within Synaptic Clefts and Play Distinct Roles in Synaptogenesis. Nakayama M, et al. J Neurosci, 2016 Jan 13. PMID 26758847, Free PMC Article
    2. Constructing and Tuning Excitatory Cholinergic Synapses: The Multifaceted Functions of Nicotinic Acetylcholine Receptors in Drosophila Neural Development and Physiology. Rosenthal JS, et al. Front Cell Neurosci, 2021. PMID 34650404, Free PMC Article
    3. Stonewalling Drosophila stem cell differentiation by epigenetic controls. Maines JZ, et al. Development, 2007 Apr. PMID 17344229
    4. Transcriptional Programs of Circuit Assembly in the Drosophila Visual System. Kurmangaliyev YZ, et al. Neuron, 2020 Dec 23. PMID 33125872
    5. Identification of proteasome components required for apical localization of Chaoptin using functional genomics. Yano H, et al. J Neurogenet, 2012 Mar. PMID 22417167

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Hig-anchoring scaffold protein
    Names
    CG10186-PA
    CG10186-PC
    CG10186-PD
    CG10186-PG
    CG10186-PH
    Hasp-PA
    Hasp-PC
    Hasp-PD
    Hasp-PG
    Hasp-PH

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19508953..19517204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136134.7 → NP_609978.4  Hig-anchoring scaffold protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609978.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNP2, Q8INW2
      Related
      FBpp0080818
      Conserved Domains (4) summary
      cd00033
      Location:307 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:365 → 420
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:114 → 360
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:515 → 576
      Sushi; Sushi repeat (SCR repeat)

    2. NM_001144370.3 → NP_001137842.2  Hig-anchoring scaffold protein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137842.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNP2, B7YZX0
      Conserved Domains (4) summary
      cd00033
      Location:307 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:365 → 420
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:114 → 360
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:515 → 576
      Sushi; Sushi repeat (SCR repeat)

    3. NM_001169545.2 → NP_001163016.1  Hig-anchoring scaffold protein, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163016.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNP2, B7YZX0
      Conserved Domains (4) summary
      cd00033
      Location:307 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:365 → 420
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:114 → 360
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:515 → 576
      Sushi; Sushi repeat (SCR repeat)

    4. NM_165306.4 → NP_724204.1  Hig-anchoring scaffold protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNP2, Q9VIU9
      Related
      FBpp0080819
      Conserved Domains (4) summary
      cd00033
      Location:307 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:365 → 420
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:114 → 360
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:515 → 576
      Sushi; Sushi repeat (SCR repeat)

    5. NM_001144368.2 → NP_001137840.1  Hig-anchoring scaffold protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q058W1
      Conserved Domains (1) summary
      PHA02927
      Location:112 → 300
      PHA02927; secreted complement-binding protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZX0 B7YZX0
    Q058W1 Q058W1
    Q8INW2 Q8INW2
    Q9VIU9 Q9VIU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous