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    Tsp42Ej Tetraspanin 42Ej [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp42Ejprovided by FlyBase
    Official Full Name
    Tetraspanin 42Ejprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033132
    Locus tag
    Dmel_CG12143
    See related
    AllianceGenome:FB:FBgn0033132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12143; Dm.Tsp42Ej; Dmel\CG12143; sun; Sun; tsp42ej
    Summary
    Involved in cellular response to high light intensity and endocytosis. Located in lysosome. Is expressed in several structures, including adult head; embryonic esophagus; embryonic head epidermis; embryonic/larval garland cell; and ganglia. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 5. Orthologous to several human genes including TSPAN1 (tetraspanin 1); TSPAN12 (tetraspanin 12); and TSPAN18 (tetraspanin 18). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp42Ej in Genome Data Viewer
    Location:
    42E5-42E5; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7040136..7042762)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2927641..2930267)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42Ei Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Tetraspanin 42Ek Neighboring gene Tetraspanin 42El Neighboring gene late bloomer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overlapping but Distinct Sequences Play Roles in the Insulator and Promoter Activities of the Drosophila BEAF-Dependent scs' Insulator. Maharjan M, et al. Genetics, 2020 Aug. PMID 32554599, Free PMC Article
    2. Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. Venkatachalam K, et al. J Biol Chem, 2006 Jun 23. PMID 16606612, Free PMC Article
    3. Prolonged G(q) activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity. Han J, et al. EMBO J, 2007 Dec 12. PMID 18034157, Free PMC Article
    4. Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway. Lee SJ, et al. Curr Biol, 2004 Dec 14. PMID 15589149
    5. Use of a Drosophila model to identify genes regulating Plasmodium growth in the mosquito. Brandt SM, et al. Genetics, 2008 Nov. PMID 18791251, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sun protein was distributed primarily in lysosomes, and functioned in light-induced degradation of rhodopsin.
      Title: A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to high light intensity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraspanin 42Ej
    Names
    CG12143-PA
    Tsp42Ej-PA
    sunglass
    sunglasses
    tetraspanin 42E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7040136..7042762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078912.3 → NP_523636.1  tetraspanin 42Ej [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523636.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3Z2
      Related
      FBpp0088101
      Conserved Domains (2) summary
      cd03127
      Location:97 → 183
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:11 → 211
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3Z2 Q7K3Z2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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