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    Fkbp14 FK506 binding protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 231997, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fkbp14provided by MGI
    Official Full Name
    FK506 binding protein 14provided by MGI
    Primary source
    MGI:MGI:2387639
    See related
    Ensembl:ENSMUSG00000038074 AllianceGenome:MGI:2387639
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FKBP22; FKBP-14
    Summary
    Predicted to enable calcium ion binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be located in endoplasmic reticulum lumen. Is expressed in cerebral cortex ventricular layer; cranium; jaw; and thoracic segment skeleton. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 15.3), bladder adult (RPKM 8.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Fkbp14 in Genome Data Viewer
    Location:
    6 B3; 6 27.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54554590..54574329, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54577602..54597344, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene predicted gene, 44026 Neighboring gene secernin 1 Neighboring gene predicted gene, 52863 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 Neighboring gene STARR-seq mESC enhancer starr_15954 Neighboring gene predicted gene, 34249 Neighboring gene maturin, neural progenitor differentiation regulator homolog (Xenopus) Neighboring gene predicted gene, 44008

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP14
    Names
    PPIase FKBP14
    rotamase
    NP_001350721.1
    NP_001350722.1
    NP_001398495.1
    NP_001398496.1
    NP_001398497.1
    NP_705801.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363792.1NP_001350721.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK163384, BC024846
      Consensus CDS
      CCDS90048.1
      UniProtKB/TrEMBL
      D3YWB6, Q3TQQ3
      Related
      ENSMUSP00000112526.2, ENSMUST00000117375.2
      Conserved Domains (2) summary
      pfam13499
      Location:47110
      EF-hand_7; EF-hand domain pair
      cl27578
      Location:141
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
    2. NM_001363793.1NP_001350722.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BC034313, BY775871
      UniProtKB/TrEMBL
      Q05BQ9
      Conserved Domains (2) summary
      COG0545
      Location:2645
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
      pfam13499
      Location:51114
      EF-hand_7; EF-hand domain pair
    3. NM_001411566.1NP_001398495.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC084800
    4. NM_001411567.1NP_001398496.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC084800
      UniProtKB/TrEMBL
      Q05BQ9
    5. NM_001411568.1NP_001398497.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC084800
    6. NM_153573.2NP_705801.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 1 precursor

      See identical proteins and their annotated locations for NP_705801.1

      Status: VALIDATED

      Source sequence(s)
      AK081692, BC024846, BY775871
      Consensus CDS
      CCDS20157.1
      UniProtKB/Swiss-Prot
      P59024
      UniProtKB/TrEMBL
      Q542Q0
      Related
      ENSMUSP00000046070.7, ENSMUST00000046520.13
      Conserved Domains (3) summary
      pfam00254
      Location:38132
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:141204
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:142204
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RNA

    1. NR_177283.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084800
    2. NR_177284.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084800
      Related
      ENSMUST00000155047.6
    3. NR_177285.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084800
    4. NR_177286.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084800

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      54554590..54574329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)