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    YIH1 Yih1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850423, updated on 9-Dec-2024

    Summary

    Official Symbol
    YIH1
    Official Full Name
    Yih1p
    Primary source
    SGD:S000000655
    Locus tag
    YCR059C
    See related
    AllianceGenome:SGD:S000000655; FungiDB:YCR059C; VEuPathDB:YCR059C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables actin monomer binding activity; protein kinase inhibitor activity; and ribosome binding activity. Involved in negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See YIH1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (223454..224230, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Ctr86p Neighboring gene snoRNA-binding rRNA-processing protein PWP2 Neighboring gene Tah1p Neighboring gene Tvs1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding  
    enables actin monomer binding PubMed 
    enables protein kinase inhibitor activity PubMed 
    enables ribosome binding PubMed 
    Process Evidence Code Pubs
    involved_in GCN2-mediated signaling  
    involved_in negative regulation of protein phosphorylation PubMed 
    involved_in regulation of translation  
    involved_in regulation of translational initiation  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    Yih1p
    NP_009985.1
    • Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      223454..224230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178770.1 → NP_009985.1  TPA: Yih1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009985.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR64, P25637
      UniProtKB/TrEMBL
      A6ZTN5, B3LUB9, B5VEZ4, C8Z4E8, G2WA71
      Conserved Domains (1) summary
      COG1739
      Location:9 → 244
      YIH1; Putative translation regulator, IMPACT (imprinted ancient) protein family [General function prediction only]
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