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    TIP41 Tip41p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856153, updated on 9-Dec-2024

    Summary

    Official Symbol
    TIP41
    Official Full Name
    Tip41p
    Primary source
    SGD:S000006244
    Locus tag
    YPR040W
    See related
    AllianceGenome:SGD:S000006244; FungiDB:YPR040W; VEuPathDB:YPR040W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein phosphatase activator activity. Acts upstream of or within negative regulation of TORC1 signaling. Located in cytoplasm and nucleus. Orthologous to human TIPRL (TOR signaling pathway regulator). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See TIP41 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (647305..648375)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Spo24p Neighboring gene flavin-linked sulfhydryl oxidase Neighboring gene Irc16p Neighboring gene translation initiation factor eIF5 Neighboring gene Puf2p

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function  
    enables protein phosphatase activator activity  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in cytosol  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    Tip41p
    NP_015365.1
    • Tap42p-interacting protein; negative regulator of the TORC1 signaling pathway that activates the type 2A-related phosphatase Sit4p by binding and antagonizing Tap42p, a SIT4 inhibitor; proposed to be part of a feedback loop to amplify Sit4p activity when TORC1 is inactivated; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      647305..648375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184137.1 → NP_015365.1  TPA: Tip41p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015365.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W449, Q12199
      UniProtKB/TrEMBL
      A6ZWT2, B3LLA0, C7GQ99, C8ZJ65, G2WPL7, N1NVJ8
      Conserved Domains (1) summary
      pfam04176
      Location:130 → 312
      TIP41; TIP41-like family
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