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    sloth2 sloth 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 7354414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sloth2provided by FlyBase
    Official Full Name
    sloth 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0259204
    Locus tag
    Dmel_CG42308
    See related
    AllianceGenome:FB:FBgn0259204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14428; CG42308; Dmel\CG42308; Sloth2
    Summary
    Involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Is expressed in adult head and organism. Orthologous to human UQCC6 (ubiquinol-cytochrome c reductase complex assembly factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sloth2 in Genome Data Viewer
    Location:
    6E4-6E4; 1-18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7011357..7012137)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6905390..6906170)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Innexin 2 Neighboring gene carmine Neighboring gene sloth 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila. Bosch JA, et al. Elife, 2022 Nov 8. PMID 36346220, Free PMC Article
    2. Gene Knock-Ins in Drosophila Using Homology-Independent Insertion of Universal Donor Plasmids. Bosch JA, et al. Genetics, 2020 Jan. PMID 31685521, Free PMC Article
    3. Mitochondrial Neurodegeneration: Lessons from Drosophila melanogaster Models. Brischigliaro M, et al. Biomolecules, 2023 Feb 16. PMID 36830747, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sloth 2
    Names
    CG42308-PA
    CG42308-PB
    sloth2-PA
    sloth2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7011357..7012137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144699.2 → NP_001138171.1  sloth 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z0X7
      Conserved Domains (1) summary
      pfam14990
      Location:2 → 44
      DUF4516; Domain of unknown function (DUF4516)

    2. NM_001144700.3 → NP_001138172.1  sloth 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138172.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z0X7
      Conserved Domains (1) summary
      pfam14990
      Location:2 → 44
      DUF4516; Domain of unknown function (DUF4516)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0X7 B7Z0X7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials