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    MLP2 Mlp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854657, updated on 9-Dec-2024

    Summary

    Official Symbol
    MLP2
    Official Full Name
    Mlp2p
    Primary source
    SGD:S000001411
    Locus tag
    YIL149C
    See related
    AllianceGenome:SGD:S000001411; FungiDB:YIL149C; VEuPathDB:YIL149C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ribonucleoprotein complex binding activity. Involved in several processes, including negative regulation of protein import into nucleus during spindle assembly checkpoint; nucleocytoplasmic transport; and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Located in nuclear envelope; nucleoplasm; and spindle pole body. Part of nuclear pore nuclear basket. Used to study lung cancer. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See MLP2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (63028..68067, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Esl1p Neighboring gene Mcm10p Neighboring gene ubiquitin-ribosomal 60S subunit protein L40A fusion protein Neighboring gene histidine kinase

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in mitochondrion PubMed 
    located_in nuclear envelope PubMed 
    located_in nuclear envelope  
    part_of nuclear pore  
    part_of nuclear pore  
    part_of nuclear pore nuclear basket PubMed 
    located_in nucleoplasm PubMed 
    located_in nucleus  
    located_in spindle pole body  
    located_in spindle pole body PubMed 

    General protein information

    Preferred Names
    Mlp2p
    NP_012117.3
    • Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      63028..68067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179497.3 → NP_012117.3  TPA: Mlp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012117.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVD8, P40457
      UniProtKB/TrEMBL
      A6ZVC7
      Conserved Domains (3) summary
      COG1196
      Location:591 → 1417
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:1309 → 1670
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR02168
      Location:59 → 988
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
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