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    TFC8 transcription factor TFIIIC subunit TFC8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856100, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TFC8
    Official Full Name
    transcription factor TFIIIC subunit TFC8
    Primary source
    SGD:S000005928
    Locus tag
    YPL007C
    See related
    AllianceGenome:SGD:S000005928; FungiDB:YPL007C; VEuPathDB:YPL007C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to DNA binding activity, bending; RNA polymerase III type 1 promoter sequence-specific DNA binding activity; and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Involved in 5S class rRNA transcription by RNA polymerase III. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TFC8 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (542082..543848, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rqc2p Neighboring gene DNA helicase Neighboring gene sphingolipid transporter Neighboring gene Aep3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, proteolytic analysis, reconstitution, and crystallization of the tau60/tau91 subcomplex of yeast TFIIIC. Mylona A, et al. Protein Expr Purif, 2006 Feb. PMID 16115780
    2. Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly. Mylona A, et al. Mol Cell, 2006 Oct 20. PMID 17052456
    3. The two DNA-binding domains of yeast transcription factor tau as observed by scanning transmission electron microscopy. Schultz P, et al. EMBO J, 1989 Dec 1. PMID 2684647, Free PMC Article
    4. A subunit of yeast TFIIIC participates in the recruitment of TATA-binding protein. Deprez E, et al. Mol Cell Biol, 1999 Dec. PMID 10567530, Free PMC Article
    5. On the subunit composition, stoichiometry, and phosphorylation of the yeast transcription factor TFIIIC/tau. Conesa C, et al. J Biol Chem, 1993 Aug 25. PMID 7688737

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 5S class rRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIIC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor TFIIIC subunit TFC8
    NP_015318.1
    • Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      542082..543848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183821.1 → NP_015318.1  TPA: transcription factor TFIIIC subunit TFC8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015318.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W405, Q12308
      UniProtKB/TrEMBL
      A6ZWN9, B3LL55, B5VTF5, C7GV51, C8ZJ19, N1NXE3
      Conserved Domains (2) summary
      sd00039
      Location:88 → 122
      7WD40; WD40 repeat [structural motif]
      pfam12660
      Location:515 → 585
      zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12308.1

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