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    Hibch 3-hydroxyisobutyryl-CoA hydrolase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hibchprovided by FlyBase
    Official Full Name
    3-hydroxyisobutyryl-CoA hydrolaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038326
    Locus tag
    Dmel_CG5044
    See related
    AllianceGenome:FB:FBgn0038326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5044; CT16187; Dmel\CG5044; HIBCH
    Summary
    Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in 3-hydroxyisobutryl-CoA hydrolase deficiency. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hibch in Genome Data Viewer
    Location:
    88F1-88F1; 3-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15357229..15359263)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11182951..11184985)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TRAPP subunit 33 Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 4 Neighboring gene Autophagy-related 4b Neighboring gene Component of oligomeric golgi complex 2 Neighboring gene Translin associated factor X Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in valine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxyisobutyryl-CoA hydrolase
    Names
    CG5044-PA
    CG5044-PB
    Hibch-PA
    Hibch-PB
    NP_650453.3
    NP_732020.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15357229..15359263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169649.2 → NP_732020.2  3-hydroxyisobutyryl-CoA hydrolase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732020.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BP1
      Related
      FBpp0082547
      Conserved Domains (2) summary
      PRK05617
      Location:44 → 376
      PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
      pfam16113
      Location:56 → 374
      ECH_2; Enoyl-CoA hydratase/isomerase

    2. NM_142196.3 → NP_650453.3  3-hydroxyisobutyryl-CoA hydrolase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650453.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960K8, Q9VF79
      Related
      FBpp0082546
      Conserved Domains (2) summary
      PRK05617
      Location:43 → 375
      PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
      pfam16113
      Location:55 → 373
      ECH_2; Enoyl-CoA hydratase/isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BP1 Q86BP1
    Q960K8 Q960K8

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