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    Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 [ Mus musculus (house mouse) ]

    Gene ID: 16513, updated on 4-Jan-2025

    Summary

    Official Symbol
    Kcnj10provided by MGI
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 10provided by MGI
    Primary source
    MGI:MGI:1194504
    See related
    Ensembl:ENSMUSG00000044708 AllianceGenome:MGI:1194504
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BIR10; BIRK-1; Kir1.2; Kir4.1
    Summary
    Enables inward rectifier potassium channel activity. Involved in cellular response to potassium ion and non-motile cilium assembly. Acts upstream of or within several processes, including adult walking behavior; glutamate reuptake; and regulation of resting membrane potential. Located in astrocyte projection; basolateral plasma membrane; and cell body. Is active in ciliary base. Is expressed in several structures, including brain; cochlea; genitourinary system; spinal cord; and stomach. Used to study EAST syndrome. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in cerebellum adult (RPKM 42.3), frontal lobe adult (RPKM 31.1) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Kcnj10 in Genome Data Viewer
    Location:
    1 H3; 1 79.69 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172168777..172201652)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172341210..172374085)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11698 Neighboring gene immunoglobulin superfamily, member 8 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 9 Neighboring gene STARR-positive B cell enhancer ABC_E3331 Neighboring gene STARR-positive B cell enhancer ABC_E4390 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class M Neighboring gene STARR-positive B cell enhancer mm9_chr1:174340789-174341090 Neighboring gene STARR-seq mESC enhancer starr_03060 Neighboring gene STARR-positive B cell enhancer ABC_E5854 Neighboring gene STARR-positive B cell enhancer ABC_E5855 Neighboring gene STARR-positive B cell enhancer ABC_E2020 Neighboring gene ribosomal protein SA pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables identical protein binding  
    enables inward rectifier potassium channel activity  
    enables inward rectifier potassium channel activity PubMed 
    enables inward rectifier potassium channel activity  
    enables potassium channel activity PubMed 
    enables protein binding PubMed 
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in L-glutamate import  
    acts_upstream_of_or_within adult walking behavior PubMed 
    involved_in cellular response to potassium ion PubMed 
    acts_upstream_of_or_within central nervous system myelination PubMed 
    acts_upstream_of_or_within establishment of localization in cell PubMed 
    acts_upstream_of_or_within glutamate reuptake PubMed 
    involved_in membrane hyperpolarization  
    involved_in non-motile cilium assembly PubMed 
    acts_upstream_of_or_within oligodendrocyte development PubMed 
    acts_upstream_of_or_within potassium ion homeostasis PubMed 
    involved_in potassium ion import across plasma membrane  
    involved_in potassium ion import across plasma membrane  
    acts_upstream_of_or_within potassium ion transmembrane transport PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport  
    acts_upstream_of_or_within potassium ion transport PubMed 
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity PubMed 
    acts_upstream_of_or_within regulation of membrane potential PubMed 
    involved_in regulation of monoatomic ion transmembrane transport  
    acts_upstream_of_or_within regulation of resting membrane potential PubMed 
    acts_upstream_of_or_within visual perception PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in astrocyte projection PubMed 
    located_in astrocyte projection  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    located_in cell body PubMed 
    is_active_in ciliary base PubMed 
    located_in microvillus  
    part_of monoatomic ion channel complex  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    located_in presynapse  

    General protein information

    Preferred Names
    ATP-sensitive inward rectifier potassium channel 10
    Names
    inward rectifier K(+) channel Kir4.1
    potassium channel, inwardly rectifying subfamily J member 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039484.1NP_001034573.1  ATP-sensitive inward rectifier potassium channel 10

      See identical proteins and their annotated locations for NP_001034573.1

      Status: VALIDATED

      Source sequence(s)
      AC074311, AK044640, AK048864
      Consensus CDS
      CCDS15512.1
      UniProtKB/Swiss-Prot
      Q9JM63
      UniProtKB/TrEMBL
      B9EIV1, Q56VN0
      Related
      ENSMUSP00000054356.4, ENSMUST00000056136.4
      Conserved Domains (2) summary
      pfam01007
      Location:31172
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179354
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      172168777..172201652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496677.5XP_006496740.3  ATP-sensitive inward rectifier potassium channel 10 isoform X1

      UniProtKB/TrEMBL
      Q499F6
      Conserved Domains (2) summary
      pfam01007
      Location:129269
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:276451
      IRK_C; Inward rectifier potassium channel C-terminal domain

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