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    FRYL FRY like transcription coactivator [ Homo sapiens (human) ]

    Gene ID: 285527, updated on 22-Dec-2024

    Summary

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    Official Symbol
    FRYLprovided by HGNC
    Official Full Name
    FRY like transcription coactivatorprovided by HGNC
    Primary source
    HGNC:HGNC:29127
    See related
    Ensembl:ENSG00000075539 MIM:620798; AllianceGenome:HGNC:29127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOR2; PCBS; AF4p12; KIAA0826
    Summary
    Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon (RPKM 15.9), lymph node (RPKM 5.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FRYL in Genome Data Viewer
    Location:
    4p11
    Exon count:
    70
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (48497357..48780279, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (48464386..48746848, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48499374..48782296, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SLAIN motif family member 2 Neighboring gene U6 snRNA-associated Sm-like protein LSm2 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:48491403-48491940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15411 Neighboring gene solute carrier family 10 member 4 Neighboring gene zygote arrest 1 Neighboring gene RNA, U5E small nuclear 3, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3875 Neighboring gene Sharpr-MPRA regulatory region 7734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15412 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15414 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:48832895-48833458 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:48833459-48834021 Neighboring gene OCIA domain containing 1 Neighboring gene OCIAD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15415 Neighboring gene OCIA domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features. Pan X, et al. Am J Hum Genet, 2024 Apr 4. PMID 38479391, Free PMC Article
    2. Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia. Sait SN, et al. Cancer Genet Cytogenet, 2007 Sep. PMID 17854671
    3. AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner. Hayette S, et al. Cancer Res, 2005 Aug 1. PMID 16061630
    4. Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Xiong S, et al. Structure, 2018 Aug 7. PMID 29983373, Free PMC Article
    5. Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. Robinson BW, et al. Blood, 2008 Apr 1. PMID 18195096, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features.
      Title: De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features.
    2. The activation segment of NDR1 influences interaction with MST1/MST2 and Furry.
      Title: Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
    3. Thus, t(4;11)(p12;q23) with MLL and FRYL involvement represents a new recurring 11q23 translocation, to date seen only in therapy-related acute leukemias.
      Title: Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16177, DKFZp686E205

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein furry homolog-like
    Names
    ALL1-fused gene from chromosome 4p12 protein
    FRY-like
    furry homolog-like
    furry-like
    mor2 cell polarity protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015030.2 → NP_055845.1  protein furry homolog-like

      See identical proteins and their annotated locations for NP_055845.1

      Status: VALIDATED

      Source sequence(s)
      AC068037, AC096952
      Consensus CDS
      CCDS43227.1
      UniProtKB/Swiss-Prot
      O94915, O95640, Q8WTZ5, Q9NT40
      UniProtKB/TrEMBL
      A0A2C9F2R7
      Related
      ENSP00000351113.4, ENST00000358350.9
      Conserved Domains (3) summary
      pfam14222
      Location:117 → 649
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2001 → 2254
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:687 → 1859
      MOR2-PAG1_mid; Cell morphogenesis central region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      48497357..48780279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453991.2 → XP_024309759.1  protein furry homolog-like isoform X9

      UniProtKB/TrEMBL
      A0A2C9F2R7
      Conserved Domains (3) summary
      pfam14222
      Location:117 → 664
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2016 → 2269
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:702 → 1874
      MOR2-PAG1_mid; Cell morphogenesis central region

    2. XM_024453993.2 → XP_024309761.1  protein furry homolog-like isoform X10

      UniProtKB/Swiss-Prot
      O94915, O95640, Q8WTZ5, Q9NT40
      UniProtKB/TrEMBL
      A0A2C9F2R7
      Conserved Domains (3) summary
      pfam14222
      Location:117 → 649
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2001 → 2254
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:687 → 1859
      MOR2-PAG1_mid; Cell morphogenesis central region

    3. XM_011513683.4 → XP_011511985.1  protein furry homolog-like isoform X9

      See identical proteins and their annotated locations for XP_011511985.1

      UniProtKB/TrEMBL
      A0A2C9F2R7
      Conserved Domains (3) summary
      pfam14222
      Location:117 → 664
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2016 → 2269
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:702 → 1874
      MOR2-PAG1_mid; Cell morphogenesis central region

    4. XM_005248090.6 → XP_005248147.1  protein furry homolog-like isoform X9

      See identical proteins and their annotated locations for XP_005248147.1

      UniProtKB/TrEMBL
      A0A2C9F2R7
      Conserved Domains (3) summary
      pfam14222
      Location:117 → 664
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2016 → 2269
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:702 → 1874
      MOR2-PAG1_mid; Cell morphogenesis central region

    5. XM_047450099.1 → XP_047306055.1  protein furry homolog-like isoform X9

      UniProtKB/TrEMBL
      A0A2C9F2R7

    6. XM_047450098.1 → XP_047306054.1  protein furry homolog-like isoform X8

      UniProtKB/TrEMBL
      A0A2C9F2R7

    7. XM_047450097.1 → XP_047306053.1  protein furry homolog-like isoform X6

      UniProtKB/TrEMBL
      A0A2C9F2R7

    8. XM_011513682.4 → XP_011511984.2  protein furry homolog-like isoform X7

      UniProtKB/TrEMBL
      A0A2C9F2R7
      Related
      ENSP00000422408.4, ENST00000507873.8
      Conserved Domains (3) summary
      pfam14222
      Location:209 → 741
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2093 → 2346
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:779 → 1951
      MOR2-PAG1_mid; Cell morphogenesis central region

    9. XM_024453989.2 → XP_024309757.1  protein furry homolog-like isoform X5

      UniProtKB/TrEMBL
      A0A2C9F2R7
      Conserved Domains (3) summary
      pfam14222
      Location:209 → 741
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2093 → 2346
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:779 → 1951
      MOR2-PAG1_mid; Cell morphogenesis central region

    10. XM_047450095.1 → XP_047306051.1  protein furry homolog-like isoform X4

      UniProtKB/TrEMBL
      A0A2C9F2R7

    11. XM_011513680.4 → XP_011511982.2  protein furry homolog-like isoform X2

      UniProtKB/TrEMBL
      A0A2C9F2R7
      Conserved Domains (3) summary
      pfam14222
      Location:209 → 756
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2107 → 2360
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:794 → 1965
      MOR2-PAG1_mid; Cell morphogenesis central region

    12. XM_011513681.4 → XP_011511983.2  protein furry homolog-like isoform X3

      UniProtKB/TrEMBL
      A0A2C9F2R7
      Conserved Domains (3) summary
      pfam14222
      Location:209 → 756
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2108 → 2361
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:794 → 1966
      MOR2-PAG1_mid; Cell morphogenesis central region

    13. XM_024453988.2 → XP_024309756.1  protein furry homolog-like isoform X1

      UniProtKB/TrEMBL
      A0A2C9F2R7
      Conserved Domains (3) summary
      pfam14222
      Location:209 → 756
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2108 → 2361
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:794 → 1966
      MOR2-PAG1_mid; Cell morphogenesis central region

    14. XM_024453992.2 → XP_024309760.1  protein furry homolog-like isoform X9

      UniProtKB/TrEMBL
      A0A2C9F2R7
      Conserved Domains (3) summary
      pfam14222
      Location:117 → 664
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2016 → 2269
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:702 → 1874
      MOR2-PAG1_mid; Cell morphogenesis central region

    15. XM_047450100.1 → XP_047306056.1  protein furry homolog-like isoform X11

    16. XM_005248093.6 → XP_005248150.1  protein furry homolog-like isoform X12

      See identical proteins and their annotated locations for XP_005248150.1

      Conserved Domains (2) summary
      pfam14225
      Location:1032 → 1285
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:197 → 890
      MOR2-PAG1_mid; Cell morphogenesis central region

    17. XM_011513684.4 → XP_011511986.1  protein furry homolog-like isoform X12

      See identical proteins and their annotated locations for XP_011511986.1

      Conserved Domains (2) summary
      pfam14225
      Location:1032 → 1285
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:197 → 890
      MOR2-PAG1_mid; Cell morphogenesis central region

    18. XM_047450101.1 → XP_047306057.1  protein furry homolog-like isoform X13

    19. XM_011513685.4 → XP_011511987.2  protein furry homolog-like isoform X14

      UniProtKB/TrEMBL
      F2Z2S2
      Related
      ENSP00000421584.1, ENST00000507711.5
      Conserved Domains (2) summary
      pfam14222
      Location:209 → 756
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14228
      Location:794 → 1559
      MOR2-PAG1_mid; Cell morphogenesis central region

    RNA

    1. XR_007096393.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      48464386..48746848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349746.1 → XP_054205721.1  protein furry homolog-like isoform X9

      UniProtKB/TrEMBL
      A0A2C9F2R7

    2. XM_054349749.1 → XP_054205724.1  protein furry homolog-like isoform X10

      UniProtKB/Swiss-Prot
      O94915, O95640, Q8WTZ5, Q9NT40
      UniProtKB/TrEMBL
      A0A2C9F2R7

    3. XM_054349747.1 → XP_054205722.1  protein furry homolog-like isoform X9

      UniProtKB/TrEMBL
      A0A2C9F2R7

    4. XM_054349745.1 → XP_054205720.1  protein furry homolog-like isoform X9

      UniProtKB/TrEMBL
      A0A2C9F2R7

    5. XM_054349738.1 → XP_054205713.1  protein furry homolog-like isoform X2

      UniProtKB/TrEMBL
      A0A2C9F2R7

    6. XM_054349742.1 → XP_054205717.1  protein furry homolog-like isoform X6

      UniProtKB/TrEMBL
      A0A2C9F2R7

    7. XM_054349737.1 → XP_054205712.1  protein furry homolog-like isoform X1

      UniProtKB/TrEMBL
      A0A2C9F2R7

    8. XM_054349740.1 → XP_054205715.1  protein furry homolog-like isoform X4

      UniProtKB/TrEMBL
      A0A2C9F2R7

    9. XM_054349741.1 → XP_054205716.1  protein furry homolog-like isoform X5

      UniProtKB/TrEMBL
      A0A2C9F2R7

    10. XM_054349744.1 → XP_054205719.1  protein furry homolog-like isoform X8

      UniProtKB/TrEMBL
      A0A2C9F2R7

    11. XM_054349739.1 → XP_054205714.1  protein furry homolog-like isoform X3

      UniProtKB/TrEMBL
      A0A2C9F2R7

    12. XM_054349743.1 → XP_054205718.1  protein furry homolog-like isoform X7

      UniProtKB/TrEMBL
      A0A2C9F2R7

    13. XM_054349748.1 → XP_054205723.1  protein furry homolog-like isoform X9

      UniProtKB/TrEMBL
      A0A2C9F2R7

    14. XM_054349750.1 → XP_054205725.1  protein furry homolog-like isoform X11

    15. XM_054349751.1 → XP_054205726.1  protein furry homolog-like isoform X12

    16. XM_054349752.1 → XP_054205727.1  protein furry homolog-like isoform X12

    17. XM_054349753.1 → XP_054205728.1  protein furry homolog-like isoform X13

    18. XM_054349754.1 → XP_054205729.1  protein furry homolog-like isoform X14

      UniProtKB/TrEMBL
      F2Z2S2

    RNA

    1. XR_008486967.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039751.1: Suppressed sequence

      Description
      NM_001039751.1: This RefSeq was temporarily suppressed because it encoded a much smaller protein than the full-length protein. It may represent a valid splicing variant but currently there are not sufficient data to support this tra
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94915.2 GenPept UniProtKB/Swiss-Prot:O94915

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