Slc43a1 solute carrier family 43, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc43a1provided by MGI
Official Full Name: solute carrier family 43, member 1provided by MGI
Primary source: MGI:MGI:1931352
See related: Ensembl:ENSMUSG00000027075 AllianceGenome:MGI:1931352
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lat3; PB39; Pov1; R00504; 2610016F07Rik
Summary: Enables L-isoleucine transmembrane transporter activity; L-leucine transmembrane transporter activity; and L-valine transmembrane transporter activity. Involved in L-leucine transport; L-valine transmembrane transport; and isoleucine transport. Acts upstream of or within L-amino acid transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; blood island; liver; neural ectoderm; and nose. Orthologous to human SLC43A1 (solute carrier family 43 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E14.5 (RPKM 49.5), liver E14 (RPKM 42.1) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.45 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (84669196..84693930)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (84838855..84863586)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA986141 (e-PCR)
- UniSTS:158978

NoName (e-PCR)
- UniSTS:234446

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-isoleucine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-isoleucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-leucine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-leucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-valine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-valine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine transport	ISO Inferred from Sequence Orthology more info
involved_in L-valine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-valine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in isoleucine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in isoleucine transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of L-leucine import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in podocyte foot	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: large neutral amino acids transporter small subunit 3

Names: L-type amino acid transporter 3; prostate cancer overexpressed gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081349.2 → NP_001074818.2 large neutral amino acids transporter small subunit 3 isoform 1

See identical proteins and their annotated locations for NP_001074818.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK046758, BX522717, CJ307166

Consensus CDS

CCDS50624.1

UniProtKB/TrEMBL

G3X8X3

Related

ENSMUSP00000028469.8, ENSMUST00000028469.14

Conserved Domains (1) summary

cd06174
Location:118 → 262

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
NM_001083809.1 → NP_001077278.1 large neutral amino acids transporter small subunit 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a distinct ATG and an isoform (3) with a shorter, distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK031215

Consensus CDS

CCDS38162.1

UniProtKB/TrEMBL

A2ATS4

Related

ENSMUSP00000107252.2, ENSMUST00000111625.2

Conserved Domains (1) summary

cd06174
Location:101 → 245

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
NM_024497.1 → NP_078773.1 large neutral amino acids transporter small subunit 3 isoform 2

See identical proteins and their annotated locations for NP_078773.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

BC053747, CJ186653, CJ307166

Consensus CDS

CCDS38163.1

UniProtKB/Swiss-Prot

A2ATS3, Q8BSM7, Q9D0H7

Related

ENSMUSP00000107251.2, ENSMUST00000111624.8

Conserved Domains (1) summary

cl28910
Location:75 → 241

MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

84669196..84693930

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500231.5 → XP_006500294.1 large neutral amino acids transporter small subunit 3 isoform X3

Conserved Domains (1) summary

cl28910
Location:51 → 217

MFS; Major Facilitator Superfamily
XM_036162592.1 → XP_036018485.1 large neutral amino acids transporter small subunit 3 isoform X2

Conserved Domains (1) summary

cd06174
Location:202 → 368

MFS; Major Facilitator Superfamily
XM_036162593.1 → XP_036018486.1 large neutral amino acids transporter small subunit 3 isoform X4
XM_036162591.1 → XP_036018484.1 large neutral amino acids transporter small subunit 3 isoform X1

Conserved Domains (1) summary

cl28910
Location:202 → 368

MFS; Major Facilitator Superfamily
XM_036162594.1 → XP_036018487.1 large neutral amino acids transporter small subunit 3 isoform X5
XM_036162595.1 → XP_036018488.1 large neutral amino acids transporter small subunit 3 isoform X7

Conserved Domains (1) summary

cl28910
Location:197 → 307

MFS; Major Facilitator Superfamily
XM_006500230.4 → XP_006500293.1 large neutral amino acids transporter small subunit 3 isoform X6

See identical proteins and their annotated locations for XP_006500293.1

UniProtKB/Swiss-Prot

A2ATS3, Q8BSM7, Q9D0H7

Related

ENSMUSP00000112642.2, ENSMUST00000121114.8

Conserved Domains (1) summary

cl28910
Location:75 → 241

MFS; Major Facilitator Superfamily