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    MMF1 isoleucine biosynthesis protein MMF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854760, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MMF1
    Official Full Name
    isoleucine biosynthesis protein MMF1
    Primary source
    SGD:S000001313
    Locus tag
    YIL051C
    See related
    AllianceGenome:SGD:S000001313; FungiDB:YIL051C; VEuPathDB:YIL051C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    IBM1
    Summary
    Predicted to enable deaminase activity. Involved in isoleucine biosynthetic process and mitochondrial translation. Located in mitochondrial matrix. Orthologous to human RIDA (reactive intermediate imine deaminase A homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MMF1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (257843..258280, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene glycerol-1-phosphatase GPP1 Neighboring gene ribosomal 60S subunit protein L34B Neighboring gene Pcl7p Neighboring gene putative polyprenol reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33. Pu YG, et al. J Struct Biol, 2011 Sep. PMID 21600990
    2. Bacterial proteins predisposed for targeting to mitochondria. Lucattini R, et al. Mol Biol Evol, 2004 Apr. PMID 14739247
    3. Schizosaccharomyces pombe Pmf1p is structurally and functionally related to Mmf1p of Saccharomyces cerevisiae. Marchini A, et al. Yeast, 2002 Jun 15. PMID 12185840
    4. A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae. Kim JM, et al. Genes Cells, 2001 Jun. PMID 11442631
    5. Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome. Oxelmark E, et al. Mol Cell Biol, 2000 Oct. PMID 11003673, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy.
      Title: Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy.
    2. Taken together, the data indicate that Mmf1p indirectly contributes to mitochondrial DNA maintenance by preventing 2-aminoacrylate stress derived from mitochondrial amino acid metabolism.
      Title: Mmf1p Couples Amino Acid Metabolism to Mitochondrial DNA Maintenance in Saccharomyces cerevisiae.
    3. The results provided the structural insights into the putative function of Mmf1 during mitochondrial protein synthesis via Mam33, a protein binding to mitochondrial ribosomal proteins.
      Title: Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in isoleucine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    isoleucine biosynthesis protein MMF1
    NP_012213.3
    • Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; induction of expression in response to stress is mediated by a Hog1p-regulated antisense RNA and gene looping; interacts genetically with mitochondrial ribosomal protein genes; MMF1 has a paralog, HMF1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      257843..258280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179401.3 → NP_012213.3  TPA: isoleucine biosynthesis protein MMF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012213.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVN0, P40185
      UniProtKB/TrEMBL
      A6ZVL8, B3LTQ7, C7GVX9, C8ZAJ5, G2WG94, N1P1M0
      Conserved Domains (1) summary
      TIGR00004
      Location:21 → 143
      TIGR00004; reactive intermediate/imine deaminase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40185.1

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