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    CG32533 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32933, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG32533provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052533
    Locus tag
    Dmel_CG32533
    See related
    AllianceGenome:FB:FBgn0052533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg12211; CG12211; CG14198; Dmel\CG32533
    Summary
    Predicted to enable RNA binding activity and helicase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Is expressed in organism and spermatozoon. Orthologous to human DHX34 (DExH-box helicase 34). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG32533 in Genome Data Viewer
    Location:
    18C7-18C7; 1-62 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19474156..19479411, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19368189..19373444, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor alpha7 Neighboring gene kekkon 5 Neighboring gene long non-coding RNA:CR43260 Neighboring gene N(alpha)-acetyltransferase 15/16 Neighboring gene narya Neighboring gene mitochondrial ribosomal protein S14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic and functional genetic evidence for distinct ecophysiological responses across complex life cycle stages. Freda PJ, et al. J Exp Biol, 2022 Jun 1. PMID 35578907
    2. Kekkon5 is an extracellular regulator of BMP signaling. Evans TA, et al. Dev Biol, 2009 Feb 1. PMID 19013143
    3. Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6. Frizzell KA, et al. RNA, 2012 Aug. PMID 22740637, Free PMC Article
    4. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. Koc EC, et al. J Biol Chem, 2000 Oct 20. PMID 10938081
    5. Tracing the origin of the compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. Sanjuán R, et al. Mol Biol Evol, 2001 Mar. PMID 11230534

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32533-PA
    CG32533-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19474156..19479411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167649.2 → NP_728244.1  uncharacterized protein Dmel_CG32533, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728244.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TP7, Q9VWI5
      Related
      FBpp0074555
      Conserved Domains (5) summary
      smart00487
      Location:155 → 327
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:560 → 640
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:163 → 298
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:358 → 490
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:792 → 897
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    2. NM_001298508.1 → NP_001285437.1  uncharacterized protein Dmel_CG32533, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TP7, Q9VWI5
      Conserved Domains (5) summary
      smart00487
      Location:155 → 327
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:560 → 640
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:163 → 298
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:358 → 490
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:792 → 897
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWI5 Q9VWI5

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