RIM21 Rim21p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RIM21
Official Full Name: Rim21p
Primary source: SGD:S000005238
Locus tag: YNL294C
See related: AllianceGenome:SGD:S000005238; FungiDB:YNL294C; VEuPathDB:YNL294C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PAL2
Summary: Involved in several processes, including ascospore formation; cellular response to alkaline pH; and invasive growth in response to glucose limitation. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RIM21 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (78659..80260, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Effect of RIM21 gene disruption on flocculation of lager yeast].
Title: [Effect of RIM21 gene disruption on flocculation of lager yeast].
The Rim101 pathway mediates adaptation to external alkalization and altered lipid asymmetry: hypothesis describing the detection of distinct stresses by the Rim21 sensor protein.
Title: The Rim101 pathway mediates adaptation to external alkalization and altered lipid asymmetry: hypothesis describing the detection of distinct stresses by the Rim21 sensor protein.
N-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane.
Title: N-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane.
PAL2 is the SCD1 (Suppressor of Clathrin Deficiency-1) locus and the Pal2 protein has characteristics of an early factor involved in clathrin-mediated endocytosis.
Title: Identification of Suppressor of Clathrin Deficiency-1 (SCD1) and Its Connection to Clathrin-Mediated Endocytosis in Saccharomyces cerevisiae.
The C-terminal cytosolic domain of Rim21 was associated with the plasma membrane under normal conditions but dissociated upon alterations in lipid asymmetry.
Title: The C-terminal Cytosolic Region of Rim21 Senses Alterations in Plasma Membrane Lipid Composition: INSIGHTS INTO SENSING MECHANISMS FOR PLASMA MEMBRANE LIPID ASYMMETRY.
plasma membrane depolarization seems to be one of the key signals for the pH sensor molecule Rim21
Title: Membrane protein Rim21 plays a central role in sensing ambient pH in Saccharomyces cerevisiae.
found that in Saccharomyces cerevisiae, Rim8 binds to both the putative seven-transmembrane pH sensor Rim21 and the ESCRT-I subunit Vps23.
Title: Recruitment of the ESCRT machinery to a putative seven-transmembrane-domain receptor is mediated by an arrestin-related protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in ascospore formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to alkaline pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in fungal-type cell wall biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fungal-type cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vacuole organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rim21p

NP_014105.1

pH sensor molecule, component of RIM101 pathway; positive regulator of cell size; has role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH