gsb-n gooseberry-neuro [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gsb-nprovided by FlyBase
Official Full Name: gooseberry-neuroprovided by FlyBase
Primary source: FLYBASE:FBgn0001147
Locus tag: Dmel_CG2692
See related: AllianceGenome:FB:FBgn0001147
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BSH-4; BSH4; CG2692; Dmel\CG2692; gsb; Gsb-n; GSB-N; gsb-neuro; gsb-p; Gsb-p; gsbn; gsbN; Gsbn; GsbN; gsbp
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neurogenesis and segment polarity determination. Located in nucleus. Is expressed in several structures, including efferent neurons; embryonic/larval hypodermal muscle cell; larval abdominal nerve; segment; and segmentally-repeated neuroblast. Human ortholog(s) of this gene implicated in Waardenburg syndrome (multiple); alveolar rhabdomyosarcoma; congenital myopathy 19; and craniofacial-deafness-hand syndrome. Orthologous to human PAX3 (paired box 3) and PAX7 (paired box 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (25040383..25052331, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20927906..20939854, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

gsb and gsbn share overlapping functions in segmentation and the central nervous system.
Title: Differential and redundant functions of gooseberry and gooseberry neuro in the central nervous system and segmentation of the Drosophila embryo.
Data show that the gooseberry/gooseberry-neuro (gsb/gsb-n) transcription factor genes act to specify MP3 cell fate.
Title: Formation and specification of a Drosophila dopaminergic precursor cell.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in segment polarity determination	IEP Inferred from Expression Pattern more info	PubMed
involved_in segment polarity determination	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

Names: CG2692-PA; gooseberry; gooseberry neuro; gooseberry proximal; gsb proximal; gsb-n-PA; gsb-neuro; gsb-proximal

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The following sections contain reference sequences that belong to a specific genome build. Explain