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    CG43347 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG43347provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263072
    Locus tag
    Dmel_CG43347
    See related
    AllianceGenome:FB:FBgn0263072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH11383; CG15295; CG9817; Dmel\CG43347
    Old locus tag
    Dmel_CG15295; Dmel_CG9817
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in embryonic brain; larval ventral nerve cord; organism; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG43347 in Genome Data Viewer
    Location:
    9D4-9D4; 1-32 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10602641..10620190, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10496674..10514223, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Hybrid male rescue Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab at 9Db Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene expression variation in African and European populations of Drosophila melanogaster. Hutter S, et al. Genome Biol, 2008 Jan 21. PMID 18208589, Free PMC Article
    2. A rapidly evolving MYB-related protein causes species isolation in Drosophila. Barbash DA, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12695567, Free PMC Article
    3. X-linked small GTPase and OXPHOS genes are candidates for the genetic basis of hybrid inviability in Drosophila. Hutter P. Dev Genes Evol, 2002 Nov. PMID 12424521
    4. Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism. Ding L, et al. EMBO J, 2018 Sep 3. PMID 30049710, Free PMC Article
    5. A TRiP RNAi screen to identify molecules necessary for Drosophila photoreceptor differentiation. Rylee J, et al. G3 (Bethesda), 2022 Nov 4. PMID 36218412, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG43347-PB
    CG43347-PC
    CG43347-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10602641..10620190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144713.3 → NP_001138185.2  uncharacterized protein Dmel_CG43347, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138185.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z141
      Conserved Domains (3) summary
      sd00017
      Location:1292 → 1313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1334 → 1361
      zf-H2C2_2; Zinc-finger double domain
      cl02596
      Location:1198 → 1268
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    2. NM_001272495.1 → NP_001259424.1  uncharacterized protein Dmel_CG43347, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE86
      Conserved Domains (3) summary
      sd00017
      Location:1292 → 1313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1334 → 1361
      zf-H2C2_2; Zinc-finger double domain
      cl02596
      Location:1198 → 1268
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    3. NM_132412.3 → NP_572640.2  uncharacterized protein Dmel_CG43347, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572640.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2T1
      Conserved Domains (3) summary
      sd00017
      Location:1259 → 1280
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1316 → 1343
      zf-H2C2_2; Zinc-finger double domain
      cl02596
      Location:1198 → 1268
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z141 B7Z141
    M9PE86 M9PE86
    Q9W2T1 Q9W2T1

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